PROX1

PROX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LMD
Identifiers
Aliases	PROX1, prospero homeobox 1
External IDs	MGI: 97772 HomoloGene: 2069 GeneCards: PROX1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • transcription corepressor activity • DBD domain binding • transcription factor activity, sequence-specific DNA binding • LBD domain binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • core promoter sequence-specific DNA binding • protein binding • ligand-dependent nuclear receptor binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding Cellular component • cytoplasm • nucleus Biological process • dorsal spinal cord development • olfactory placode formation • regulation of transcription, DNA-templated • positive regulation of endothelial cell proliferation • venous blood vessel morphogenesis • kidney development • lymphangiogenesis • lung development • dentate gyrus development • rhythmic process • ventricular septum morphogenesis • cardiac muscle cell differentiation • lymphatic endothelial cell differentiation • positive regulation of sarcomere organization • positive regulation of forebrain neuron differentiation • endocardium formation • hepatocyte differentiation • negative regulation of transcription from RNA polymerase II promoter • negative regulation of sequence-specific DNA binding transcription factor activity • lymph vessel development • hepatocyte cell migration • transcription, DNA-templated • optic placode formation involved in camera-type eye formation • skeletal muscle thin filament assembly • neuronal stem cell population maintenance • positive regulation of endothelial cell migration • positive regulation of transcription, DNA-templated • positive regulation of heart growth • ventricular cardiac muscle tissue morphogenesis • positive regulation of neural precursor cell proliferation • retina morphogenesis in camera-type eye • multicellular organism development • regulation of transcription involved in lymphatic endothelial cell fate commitment • negative regulation of viral genome replication • brain development • branching involved in pancreas morphogenesis • positive regulation of cell cycle • lens development in camera-type eye • response to nutrient levels • hepatocyte proliferation • positive regulation of cell cycle checkpoint • regulation of circadian rhythm • circadian rhythm • acinar cell differentiation • neural tube development • neuron differentiation • positive regulation of cell proliferation • lens morphogenesis in camera-type eye • positive regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of bile acid biosynthetic process • embryonic retina morphogenesis in camera-type eye • regulation of gene expression • cell fate determination • pancreas development • liver development • atrial cardiac muscle tissue morphogenesis • endothelial cell differentiation • inner ear development • negative regulation of transcription, DNA-templated • ventricular cardiac myofibril assembly • otic placode formation • aorta smooth muscle tissue morphogenesis • cerebellar granule cell differentiation • negative regulation of cell proliferation • positive regulation of transcription from RNA polymerase II promoter • lens fiber cell morphogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5629	19130
Ensembl	ENSG00000117707	ENSMUSG00000010175
UniProt	Q92786	P48437
RefSeq (mRNA)	NM_001270616 NM_002763	NM_008937
RefSeq (protein)	NP_001257545 NP_002754	NP_032963.1 NP_032963
Location (UCSC)	Chr 1: 213.98 – 214.04 Mb	Chr 1: 190.12 – 190.17 Mb
PubMed search

2LMD

5629

19130

ENSG00000117707

ENSMUSG00000010175

Q92786

P48437

NM_001270616
NM_002763

NM_008937

NP_001257545
NP_002754

NP_032963.1
NP_032963

Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene.

PROX1 has been shown to interact with EP300.

PROX1 is produced primarily in the dentate gyrus in the mouse, and in the dentate gyrus and white matter in humans. Gene expression data for mouse, human and macaque from the Allen Brain Atlases can be found here.

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Wikipedia