EP300

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1L3E, 1P4Q, 2K8F, 2MH0, 2MZD, 3BIY, 3I3J, 3IO2, 3P57, 3T92, 4BHW, 4PZR, 4PZS, 4PZT, 5BT3

Identifiers

Aliases

EP300, KAT3B, RSTS2, p300, E1A binding protein p300

External IDs

MGI: 1276116 HomoloGene: 1094 GeneCards: EP300

Targeted by Drug

curcumin, epigallocatechin gallate, plumbagin

Gene ontology
Molecular function	• RNA polymerase II activating transcription factor binding • protein C-terminus binding • RNA polymerase II core promoter sequence-specific DNA binding • transcription factor binding • transcription cofactor activity • metal ion binding • transferase activity, transferring acyl groups • transferase activity • beta-catenin binding • pre-mRNA intronic binding • RNA polymerase II transcription factor binding • zinc ion binding • chromatin binding • damaged DNA binding • protein binding • acetyltransferase activity • DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription coactivator activity • p53 binding • nuclear hormone receptor binding • androgen receptor binding • chromatin DNA binding • histone acetyltransferase activity • lysine N-acetyltransferase activity, acting on acetyl phosphate as donor • activating transcription factor binding • core promoter binding • peptide N-acetyltransferase activity • peptide-lysine-N-acetyltransferase activity
Cellular component	• nucleus • histone acetyltransferase complex • transcription factor complex • nucleoplasm • cytoplasm • cytosol • protein complex
Biological process	• somitogenesis • positive regulation of gene expression, epigenetic • rhythmic process • transcription from RNA polymerase II promoter • histone H2B acetylation • animal organ morphogenesis • cell cycle • B cell differentiation • apoptotic process • regulation of transcription, DNA-templated • lung development • N-terminal peptidyl-lysine acetylation • platelet formation • stimulatory C-type lectin receptor signaling pathway • transcription, DNA-templated • positive regulation of transcription, DNA-templated • heart development • histone acetylation • regulation of transcription from RNA polymerase II promoter in response to hypoxia • viral process • protein acetylation • Notch signaling pathway • cellular response to UV • protein stabilization • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of transcription from RNA polymerase II promoter • nervous system development • regulation of autophagy • regulation of androgen receptor signaling pathway • positive regulation of protein binding • positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response • fat cell differentiation • positive regulation by host of viral transcription • megakaryocyte development • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • internal protein amino acid acetylation • regulation of cell cycle • regulation of tubulin deacetylation • positive regulation of gene expression • histone H4 acetylation • regulation of cellular response to heat • transcription-coupled nucleotide-excision repair • skeletal muscle tissue development • positive regulation of type I interferon production • response to estrogen • response to hypoxia • regulation of signal transduction by p53 class mediator • internal peptidyl-lysine acetylation • beta-catenin-TCF complex assembly • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • macrophage derived foam cell differentiation • circadian rhythm • protein deubiquitination • positive regulation of transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2033


328572

Ensembl


ENSG00000100393


ENSMUSG00000055024

UniProt


Q09472


B2RWS6

RefSeq (mRNA)


NM_001429


NM_177821

RefSeq (protein)


NP_001420


NP_808489.4 NP_808489

Location (UCSC)

Chr 22: 41.09 – 41.18 Mb

Chr 15: 81.59 – 81.65 Mb

PubMed search

1L3E, 1P4Q, 2K8F, 2MH0, 2MZD, 3BIY, 3I3J, 3IO2, 3P57, 3T92, 4BHW, 4PZR, 4PZS, 4PZT, 5BT3

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