PRG4
| PRG4 | |||||||||||||||||
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| Aliases | PRG4, CACP, HAPO, JCAP, MSF, SZP, bG174L6.2, proteoglycan 4 | ||||||||||||||||
| External IDs | HomoloGene: 130465 GeneCards: PRG4 | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 1: 186.3 – 186.31 Mb | n/a | |||||||||||||||
| PubMed search | n/a | ||||||||||||||||
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NM_005807
NM_001127708
NM_001127709
NM_001127710
NM_001303232
n/a
NP_001121180
NP_001121181
NP_001121182
NP_001290161
NP_005798
n/a
Proteoglycan 4 or lubricin is a proteoglycan that in humans is encoded by the PRG4 gene. This proteoglycan acts as a joint/boundary lubricant.
Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin, MSF, and SZP are now collectively known as Proteoglycan 4 (hence PRG4 for the gene nomenclature). The expression of lubricin has also been detected and the protein localized in tendon,meniscus,lung, liver, heart, bone,ligament, muscle, and skin.
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Wikipedia