PPP2CB

PPP2CB
Identifiers
Aliases	PPP2CB, PP2Abeta, PP2CB, protein phosphatase 2 catalytic subunit beta
External IDs	MGI: 1321161 HomoloGene: 37889 GeneCards: PPP2CB
Gene ontology Molecular function • phosphoprotein phosphatase activity • metal ion binding • protein binding • hydrolase activity • protein serine/threonine phosphatase activity • protein C-terminus binding Cellular component • cytoplasm • cytosol • spindle pole • protein phosphatase type 2A complex • chromosome • chromosome, centromeric region • extracellular exosome • cytoskeleton • nucleus Biological process • response to antibiotic • response to endoplasmic reticulum stress • apoptotic mitochondrial changes • regulation of gene expression • response to hydrogen peroxide • proteasome-mediated ubiquitin-dependent protein catabolic process • protein dephosphorylation • negative regulation of Ras protein signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5516	19053
Ensembl	ENSG00000104695	ENSMUSG00000009630
UniProt	P62714	P62715
RefSeq (mRNA)	NM_004156 NM_001009552	NM_017374
RefSeq (protein)	NP_001009552	NP_059070
Location (UCSC)	Chr 8: 30.77 – 30.81 Mb	Chr 8: 33.6 – 33.62 Mb
PubMed search

5516

19053

ENSG00000104695

ENSMUSG00000009630

P62714

P62715

NM_004156
NM_001009552

NM_017374

NP_001009552

NP_059070

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP2CB gene.

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. Two transcript variants encoding the same protein have been identified for this gene.

PPP2CB has been shown to interact with TLX1,PPP2R1B and PPP2R1A.

PPP2CA

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Wikipedia