PINK1

PINK1
Identifiers
Aliases	PINK1, BRPK, PARK6, PTEN induced putative kinase 1
External IDs	MGI: 1916193 HomoloGene: 32672 GeneCards: PINK1
Gene ontology Molecular function • C3HC4-type RING finger domain binding • kinase activity • ATP binding • protein kinase activity • metal ion binding • protein serine/threonine kinase activity • calcium-dependent protein kinase activity • peptidase activator activity • magnesium ion binding • transferase activity • protease binding • protein binding • nucleotide binding • protein kinase B binding • ubiquitin protein ligase binding Cellular component • cytoplasm • cytosol • membrane • mitochondrial intermembrane space • mitochondrion • perinuclear region of cytoplasm • cytoskeleton • nucleus • Lewy body • integral component of mitochondrial outer membrane • mitochondrial outer membrane • chromatin • TORC2 complex • integral component of membrane • ubiquitin ligase complex • mitochondrial outer membrane translocase complex • astrocyte projection • axon • cell body • mitochondrial inner membrane Biological process • negative regulation of neuron apoptotic process • positive regulation of macromitophagy in response to mitochondrial depolarization • positive regulation of mitochondrial fission • positive regulation of free ubiquitin chain polymerization • regulation of protein ubiquitination • cellular response to toxic substance • positive regulation of catecholamine secretion • regulation of synaptic vesicle transport • positive regulation of translation • protein phosphorylation • positive regulation of dopamine secretion • macroautophagy • regulation of protein complex assembly • cellular response to hypoxia • negative regulation of autophagosome assembly • positive regulation of protein kinase B signaling • positive regulation of protein dephosphorylation • ubiquitin-dependent protein catabolic process • peptidyl-serine autophosphorylation • regulation of neuron apoptotic process • response to oxidative stress • negative regulation of gene expression • positive regulation of peptidyl-serine phosphorylation • negative regulation of mitochondrial fission • positive regulation of mitochondrial electron transport, NADH to ubiquinone • positive regulation of macroautophagy • regulation of mitophagy • positive regulation of ubiquitin-protein transferase activity • negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway • protein ubiquitination • negative regulation of oxidative stress-induced cell death • negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide • positive regulation of synaptic transmission, dopaminergic • negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway • regulation of oxidative phosphorylation • phosphorylation • regulation of mitochondrion organization • regulation of hydrogen peroxide metabolic process • negative regulation of oxidative stress-induced neuron death • protein stabilization • mitochondrion organization • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of mitophagy • regulation of reactive oxygen species metabolic process • positive regulation of ATP biosynthetic process • maintenance of protein location in mitochondrion • regulation of protein targeting to mitochondrion • positive regulation of release of cytochrome c from mitochondria • respiratory electron transport chain • positive regulation of protein ubiquitination • regulation of proteasomal protein catabolic process • activation of protein kinase B activity • intracellular signal transduction • negative regulation of macroautophagy • positive regulation of protein targeting to mitochondrion • positive regulation of cristae formation • response to stress • positive regulation of peptidase activity • TORC2 signaling • regulation of mitochondrial membrane potential • autophagy • negative regulation of JNK cascade • establishment of protein localization to mitochondrion • mitophagy • peptidyl-serine phosphorylation • positive regulation of I-kappaB kinase/NF-kappaB signaling • cellular response to oxidative stress • negative regulation of reactive oxygen species metabolic process • negative regulation of apoptotic process • positive regulation of protein phosphorylation • positive regulation of histone deacetylase activity • mitochondrion to lysosome transport • regulation of cellular response to oxidative stress Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	65018	68943
Ensembl	ENSG00000158828	ENSMUSG00000028756
UniProt	Q9BXM7	Q99MQ3
RefSeq (mRNA)	NM_032409	NM_026880
RefSeq (protein)	NP_115785	NP_081156.2 NP_081156
Location (UCSC)	Chr 1: 20.63 – 20.65 Mb	Chr 4: 138.31 – 138.33 Mb
PubMed search

65018

68943

ENSG00000158828

ENSMUSG00000028756

Q9BXM7

Q99MQ3

NM_032409

NM_026880

NP_115785

NP_081156.2
NP_081156

PTEN-induced putative kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene.

It is thought to protect cells from stress-induced dysfunction. PINK1 activity causes the parkin protein to bind to depolarized mitochondria to induce autophagy of those mitochondria. PINK1 is processed by healthy mitochondria and released to trigger neuron differentiation. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson's disease.

PINK1 is synthesized as a 63000 Da protein which is often cleaved by PARL, between the 103-Alanine and the 104-Phenylalanine residues, into a 53000 Da fragment. PINK1 contains an N-terminal mitochondrial localization sequence, a putative transmembrane sequence, a Ser/Thr kinase domain, and a C-terminal regulatory sequence. The protein has been found to localize to the outer membrane of mitochondria, but can also be found throughout the cytosol. Experiments suggest the Ser/Thr kinase domain faces outward toward the cytosol, indicating a possible point of interaction with parkin.

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Wikipedia