Parkin (ligase)

PARK2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1IYF, 2JMO, 4I1F, 4I1H, 4BM9, 5C1Z, 5C23, 5C9V

Identifiers

Aliases

PARK2, parkin RBR E3 ubiquitin protein ligase, AR-JP, LPRS2, PDJ, PRKN

External IDs

OMIM: 602544 MGI: 1355296 HomoloGene: 3355 GeneCards: PARK2

Genetically Related Diseases

pancreatic cancer

Gene ontology
Molecular function	• phospholipase binding • transcription factor activity, sequence-specific DNA binding • SH3 domain binding • histone deacetylase binding • tubulin binding • cullin family protein binding • PDZ domain binding • heat shock protein binding • ubiquitin protein ligase activity involved in ERAD pathway • metal ion binding • Hsp70 protein binding • kinase binding • enzyme binding • beta-catenin binding • zinc ion binding • protein binding • ubiquitin conjugating enzyme binding • protein kinase binding • chaperone binding • transcription regulatory region sequence-specific DNA binding • ubiquitin-protein transferase activity • F-box domain binding • ubiquitin binding • identical protein binding • actin binding • ubiquitin-specific protease binding • G-protein coupled receptor binding • ubiquitin protein ligase binding • transferase activity • ubiquitin protein ligase activity
Cellular component	• cytoplasm • cytosol • mitochondrion • perinuclear region of cytoplasm • nucleus • Lewy body • SCF ubiquitin ligase complex • aggresome • endoplasmic reticulum • Golgi apparatus • Parkin-FBXW7-Cul1 ubiquitin ligase complex • ubiquitin ligase complex • LUBAC complex • protein complex • presynapse • neuron projection • mitochondrion-derived vesicle
Biological process	• negative regulation of neuron apoptotic process • protein K29-linked ubiquitination • negative regulation of insulin secretion • ERAD pathway • positive regulation of mitochondrial fission • positive regulation of macromitophagy in response to mitochondrial depolarization • positive regulation of protein catabolic process • synaptic transmission, glutamatergic • positive regulation of tumor necrosis factor-mediated signaling pathway • neuron cellular homeostasis • regulation of protein ubiquitination • cellular response to toxic substance • modulation of synaptic transmission • regulation of synaptic vesicle transport • learning • protein monoubiquitination • cellular protein catabolic process • synaptic transmission, dopaminergic • positive regulation of neurotransmitter uptake • regulation of glucose metabolic process • protein K6-linked ubiquitination • negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator • negative regulation of spontaneous neurotransmitter secretion • negative regulation by host of viral genome replication • positive regulation of DNA binding • macroautophagy • negative regulation of canonical Wnt signaling pathway • cellular response to unfolded protein • aggresome assembly • proteasome-mediated ubiquitin-dependent protein catabolic process • regulation of dopamine secretion • zinc ion homeostasis • free ubiquitin chain polymerization • regulation of transcription, DNA-templated • locomotory behavior • norepinephrine metabolic process • negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway • adult locomotory behavior • protein metabolic process • negative regulation of cell death • response to oxidative stress • protein K27-linked ubiquitination • negative regulation of gene expression • transcription, DNA-templated • response to endoplasmic reticulum stress • protein K11-linked ubiquitination • central nervous system development • negative regulation of oxidative stress-induced cell death • positive regulation of mitochondrial fusion • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • protein localization to mitochondrion • proteasomal protein catabolic process • cellular response to manganese ion • negative regulation of mitochondrial fusion • negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • protein autoubiquitination • negative regulation of neuron death • negative regulation of protein phosphorylation • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • negative regulation of primary amine oxidase activity • startle response • mitochondrial fission • regulation of mitochondrion organization • regulation of canonical Wnt signaling pathway • negative regulation of release of cytochrome c from mitochondria • protein stabilization • mitochondrion organization • protein polyubiquitination • negative regulation of transcription from RNA polymerase II promoter • regulation of reactive oxygen species metabolic process • regulation of neurotransmitter secretion • positive regulation of protein linear polyubiquitination • positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • protein K48-linked ubiquitination • dopamine uptake involved in synaptic transmission • regulation of autophagy • regulation of protein targeting to mitochondrion • protein destabilization • negative regulation of glucokinase activity • positive regulation of proteasomal protein catabolic process • cellular protein metabolic process • protein K63-linked ubiquitination • cellular response to dopamine • regulation of lipid transport • negative regulation of actin filament bundle assembly • regulation of dopamine metabolic process • regulation of mitochondrial membrane potential • autophagy • negative regulation of JNK cascade • dopamine metabolic process • positive regulation of gene expression • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of dendrite extension • negative regulation of reactive oxygen species metabolic process • positive regulation of transcription from RNA polymerase II promoter • macromitophagy • protein ubiquitination • parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • protein deubiquitination • regulation of protein stability • positive regulation of protein binding • mitochondrion to lysosome transport • regulation of cellular response to oxidative stress • negative regulation of exosomal secretion • positive regulation of retrograde transport, endosome to Golgi • negative regulation of intralumenal vesicle formation • positive regulation of protein localization to membrane • mitophagy • positive regulation of mitophagy • ER-associated ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5071


50873

Ensembl


ENSG00000185345


ENSMUSG00000023826

UniProt


O60260


Q9WVS6

RefSeq (mRNA)


NM_004562 NM_013987 NM_013988


NM_016694 NM_001317726

RefSeq (protein)


NP_004553 NP_054642 NP_054643


NP_057903.1 NP_001304655.1 NP_001304655 NP_057903

Location (UCSC)

Chr 6: 161.35 – 162.73 Mb

Chr 17: 10.84 – 12.06 Mb

PubMed search

1IYF, 2JMO, 4I1F, 4I1H, 4BM9, 5C1Z, 5C23, 5C9V

NM_004562
NM_013987
NM_013988

NM_016694
NM_001317726

NP_004553
NP_054642
NP_054643

...
Wikipedia