PARL

PARL
Identifiers
Aliases	PARL, PSARL, PSARL1, PSENIP2, RHBDS1, PRO2207, presenilin associated rhomboid like
External IDs	MGI: 1277152 HomoloGene: 10239 GeneCards: PARL
Gene ontology Molecular function • peptidase activity • serine-type peptidase activity • protein binding • hydrolase activity • serine-type endopeptidase activity • endopeptidase activity Cellular component • integral component of membrane • mitochondrial inner membrane • membrane • mitochondrion • nucleus Biological process • regulation of reactive oxygen species metabolic process • regulation of protein targeting to mitochondrion • regulation of proteolysis • proteolysis • membrane protein proteolysis • regulation of mitochondrion organization • mitochondrial calcium ion transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55486	381038
Ensembl	ENSG00000175193	ENSMUSG00000033918
UniProt	Q9H300	Q5XJY4
RefSeq (mRNA)	NM_001037639 NM_001037640 NM_018622 NM_001324436 NM_001324437 NM_001324438	NM_001005767
RefSeq (protein)	NP_001032728 NP_001311365 NP_001311366 NP_001311367 NP_061092	NP_001005767
Location (UCSC)	Chr 3: 183.83 – 183.88 Mb	Chr 16: 20.28 – 20.3 Mb
PubMed search

55486

381038

ENSG00000175193

ENSMUSG00000033918

Q9H300

Q5XJY4

NM_001324438

NM_001005767

NP_001032728
NP_001311365
NP_001311366
NP_001311367
NP_061092

NP_001005767

Presenilins-associated rhomboid-like protein, mitochondrial also known as mitochondrial intramembrane cleaving protease PARL is an protein that in humans is encoded by the PARL gene on chromosome 3. It is a member of the rhomboid family of intramembrane serine proteases. This protein is involved in signal transduction and apoptosis, as well as neurodegenerative diseases and type 2 diabetes.

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Wikipedia