PIAS4

Identifiers

PIAS4, PIASY, Piasg, ZMIZ6, PIAS-gamma, protein inhibitor of activated STAT 4

External IDs

MGI: 2136940 HomoloGene: 104136 GeneCards: PIAS4

Gene ontology
Molecular function	• DNA binding • transcription corepressor activity • zinc ion binding • metal ion binding • SUMO ligase activity • protein C-terminus binding • protein binding • ubiquitin protein ligase binding • SUMO transferase activity • transferase activity
Cellular component	• cytoplasm • PML body • nuclear matrix • transferase complex • nucleus • nucleoplasm
Biological process	• regulation of transcription, DNA-templated • positive regulation of keratinocyte apoptotic process • negative regulation of tumor necrosis factor-mediated signaling pathway • negative regulation of transcription from RNA polymerase II promoter • Wnt signaling pathway • positive regulation of protein sumoylation • protein sumoylation • transcription, DNA-templated • positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage • negative regulation of transcription, DNA-templated • double-strand break repair via nonhomologous end joining • negative regulation of NF-kappaB transcription factor activity
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


51588


59004

Ensembl


ENSG00000105229


ENSMUSG00000004934

UniProt


Q8N2W9


Q9JM05

RefSeq (mRNA)


NM_015897 NM_016149


NM_021501

RefSeq (protein)


NP_056981


NP_067476

Location (UCSC)

Chr 19: 4.01 – 4.04 Mb

Chr 10: 81.15 – 81.17 Mb

PubMed search

E3 SUMO-protein ligase PIAS4 is one of several protein inhibitor of activated STAT (PIAS) proteins. It is also known as protein inhibitor of activated STAT protein gamma (PIASg or PIASy), and is an enzyme that in humans is encoded by the PIAS4 gene.

PIAS4 has been shown to interact with Mothers against decapentaplegic homolog 6,Mothers against decapentaplegic homolog 7 and Lymphoid enhancer-binding factor 1.

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