Mothers against decapentaplegic homolog 6

SMAD6
Identifiers
Aliases	SMAD6, AOVD2, HsT17432, MADH6, MADH7, SMAD family member 6
External IDs	OMIM: 602931 MGI: 1336883 HomoloGene: 4079 GeneCards: SMAD6
Gene ontology Molecular function • DNA binding • R-SMAD binding • type I transforming growth factor beta receptor binding • co-SMAD binding • I-SMAD binding • transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity • transcription factor activity, sequence-specific DNA binding • chromatin binding • type I activin receptor binding • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • identical protein binding • transcription regulatory region DNA binding • ubiquitin protein ligase binding Cellular component • cytoplasm • transcription factor complex • intracellular • protein complex • nucleus • Golgi apparatus • cytosol • nuclear body Biological process • ureteric bud development • heart valve development • regulation of transcription, DNA-templated • ventricular septum development • zygotic specification of dorsal/ventral axis • negative regulation of SMAD protein complex assembly • response to laminar fluid shear stress • negative regulation of apoptotic process • negative regulation of transforming growth factor beta receptor signaling pathway • coronary vasculature development • BMP signaling pathway • transcription, DNA-templated • negative regulation of pathway-restricted SMAD protein phosphorylation • response to estrogen • negative regulation of BMP signaling pathway • aorta development • cell-substrate adhesion • immune response • transforming growth factor beta receptor signaling pathway • fat cell differentiation • negative regulation of cell proliferation • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • outflow tract septum morphogenesis • mitral valve morphogenesis • pulmonary valve morphogenesis • negative regulation of ossification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4091	17130
Ensembl	ENSG00000137834	ENSMUSG00000036867
UniProt	O43541	O35182
RefSeq (mRNA)	NM_001142861 NM_005585	NM_008542
RefSeq (protein)	NP_005576	NP_032568
Location (UCSC)	Chr 15: 66.7 – 66.78 Mb	Chr 9: 63.95 – 64.02 Mb
PubMed search

4091

17130

ENSG00000137834

ENSMUSG00000036867

O43541

O35182

NM_001142861
NM_005585

NM_008542

NP_005576

NP_032568

SMAD family member 6, also known as SMAD6, is a protein that in humans is encoded by the SMAD6 gene.

SMAD6 is a protein that, as its name describes, is a homolog of the Drosophila gene "mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD6 is involved in cell signalling. It acts as a regulator of TGFβ family (such as bone morphogenetic proteins) activity by competing with SMAD4 and preventing the transcription of SMAD4's gene products. There are two known isoforms of this protein.

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Wikipedia