Mothers against decapentaplegic homolog 7

SMAD7

SMURF2 SMAD7 complex.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DJY, 2LTV, 2LTW, 2LTX, 2LTY, 2LTZ, 2KXQ

Identifiers

SMAD7, CRCS3, MADH7, MADH8, SMAD family member 7

External IDs

OMIM: 602932 MGI: 1100518 HomoloGene: 4314 GeneCards: SMAD7

Gene location (Human)

Chr.	Chromosome 18 (human)

Band	No data available	Start	48,919,853 bp
Band	No data available	End	48,950,711 bp

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)

Band	No data available	Start	75,367,529 bp
Band	No data available	End	75,395,935 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• DNA binding • beta-catenin binding • type I transforming growth factor beta receptor binding • collagen binding • I-SMAD binding • activin binding • transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity • transcription factor activity, sequence-specific DNA binding • metal ion binding • protein binding • transcription regulatory region DNA binding • ubiquitin protein ligase binding
Cellular component	• cytoplasm • centrosome • transcription factor complex • plasma membrane • cell-cell adherens junction • intracellular • nucleoplasm • protein complex • catenin complex • nucleus • fibrillar center • cytosol
Biological process	• cellular response to transforming growth factor beta stimulus • regulation of ventricular cardiac muscle cell membrane depolarization • pathway-restricted SMAD protein phosphorylation • ureteric bud development • regulation of transcription, DNA-templated • adherens junction assembly • positive regulation of cell-cell adhesion • ventricular septum morphogenesis • regulation of epithelial to mesenchymal transition • negative regulation of peptidyl-threonine phosphorylation • negative regulation of transcription by competitive promoter binding • response to laminar fluid shear stress • protein stabilization • regulation of activin receptor signaling pathway • negative regulation of transcription from RNA polymerase II promoter • negative regulation of transforming growth factor beta receptor signaling pathway • BMP signaling pathway • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of BMP signaling pathway • ventricular cardiac muscle tissue morphogenesis • negative regulation of protein ubiquitination • negative regulation of cell migration • cellular protein complex localization • negative regulation of ubiquitin-protein transferase activity • artery morphogenesis • negative regulation of peptidyl-serine phosphorylation • regulation of cardiac muscle contraction • positive regulation of protein ubiquitination • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of epithelial to mesenchymal transition • positive regulation of transcription from RNA polymerase II promoter • regulation of transforming growth factor beta receptor signaling pathway • transcription, DNA-templated • transforming growth factor beta receptor signaling pathway • protein deubiquitination • negative regulation of T cell cytokine production • negative regulation of T-helper 17 type immune response • negative regulation of T-helper 17 cell differentiation • cellular response to leukemia inhibitory factor
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


4092


17131


ENSG00000101665


ENSMUSG00000025880


O15105


O35253

RefSeq (mRNA)


NM_005904 NM_001190821 NM_001190822 NM_001190823


NM_001042660 NM_008543

RefSeq (protein)


NP_001177750 NP_001177751 NP_001177752 NP_005895


NP_001036125

Location (UCSC)

Chr 18: 48.92 – 48.95 Mb

Chr 18: 75.37 – 75.4 Mb

PubMed search

2DJY, 2LTV, 2LTW, 2LTX, 2LTY, 2LTZ, 2KXQ

ENSG00000101665

ENSMUSG00000025880

NM_005904
NM_001190821
NM_001190822
NM_001190823

NM_001042660
NM_008543

NP_001177750
NP_001177751
NP_001177752
NP_005895

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Wikipedia

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