PDCD2

Identifiers

PDCD2, RP8, ZMYND7, programmed cell death 2

External IDs

MGI: 104643 HomoloGene: 1951 GeneCards: PDCD2

Gene ontology
Molecular function	• enzyme binding • DNA binding • protein binding • metal ion binding
Cellular component	• cytoplasm • extracellular exosome • nucleus
Biological process	• positive regulation of apoptotic process • positive regulation of hematopoietic stem cell proliferation • regulation of hematopoietic progenitor cell differentiation • activation of cysteine-type endopeptidase activity involved in apoptotic process • programmed cell death • apoptotic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5134


18567

Ensembl


ENSG00000071994


ENSMUSG00000014771

UniProt


Q16342


P46718

RefSeq (mRNA)

NM_001199461 NM_001199462 NM_001199463 NM_001199464 NM_002598
NM_144781


NM_008799

RefSeq (protein)

NP_001186390 NP_001186391 NP_001186392 NP_001186393 NP_002589
NP_659005


NP_032825.2 NP_032825

Location (UCSC)

Chr 6: 170.58 – 170.58 Mb

Chr 17: 15.52 – 15.53 Mb

PubMed search

NP_032825.2
NP_032825

Programmed cell death protein 2 is a protein that in humans is encoded by the PDCD2 gene.

This gene encodes a nuclear protein expressed in a variety of tissues. The rat homolog, Rp8, is transiently expressed in immature thymocytes and is thought to be involved in programmed cell death. Expression of the human gene has been shown to be repressed by BCL6, a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on PDCD2. This gene is closely linked on chromosome 6 to the gene for TBP, the TATA binding protein. Six transcripts encoding different proteins have been identified.

PDCD2 has been shown to interact with Host cell factor C1 and Parkin (ligase).

Model organisms have been used in the study of PDCD2 function. A conditional knockout mouse line called Pdcd2^{tm1b(EUCOMM)Wtsi} was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

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