Host cell factor C1

HCFC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GO6, 4N39, 4N3A, 4N3B, 4N3C
Identifiers
Aliases	HCFC1, CFF, HCF-1, HCF1, HFC1, MRX3, PPP1R89, VCAF, HCF, Host cell factor C1
External IDs	MGI: 105942 HomoloGene: 3898 GeneCards: HCFC1
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • chromatin binding • histone acetyltransferase activity (H4-K8 specific) • histone acetyltransferase activity (H4-K5 specific) • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • protein binding • identical protein binding • histone acetyltransferase activity (H4-K16 specific) • cadherin binding Cellular component • cytoplasm • Ada2/Gcn5/Ada3 transcription activator complex • membrane • SAGA-type complex • Set1C/COMPASS complex • axon • neuronal cell body • MLL1 complex • dendrite • histone acetyltransferase complex • nucleus • nucleoplasm Biological process • regulation of transcription, DNA-templated • release from viral latency • cellular response to organic cyclic compound • protein stabilization • mitochondrion organization • negative regulation of transcription from RNA polymerase II promoter • histone H4-K5 acetylation • positive regulation of gene expression • positive regulation of cell cycle • cell cycle • histone H4-K16 acetylation • viral process • histone H4-K8 acetylation • regulation of protein complex assembly • positive regulation of transcription from RNA polymerase II promoter • covalent chromatin modification • transcription from RNA polymerase II promoter • protein deubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3054	15161
Ensembl	ENSG00000172534	ENSMUSG00000031386
UniProt	P51610	Q61191
RefSeq (mRNA)	NM_005334	NM_008224
RefSeq (protein)	NP_005325	NP_032250.2 NP_032250
Location (UCSC)	Chr X: 153.95 – 153.97 Mb	Chr X: 73.94 – 73.97 Mb
PubMed search

4GO6, 4N39, 4N3A, 4N3B, 4N3C

3054

15161

ENSG00000172534

ENSMUSG00000031386

P51610

Q61191

NM_005334

NM_008224

NP_005325

NP_032250.2
NP_032250

Host cell factor 1 (HCFC1, HCF1, or HCF-1), also known as VP16-accessory protein, is a protein that in humans is encoded by the HCFC1 gene.

HCF1 is a member of the highly conserved host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear transcription coregulator is proteolytically cleaved at one or more of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains which interact through electrostatic forces.

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Wikipedia