PCSK6

PCSK6
Identifiers
Aliases	PCSK6, PACE4, SPC4, proprotein convertase subtilisin/kexin type 6
External IDs	MGI: 102897 HomoloGene: 20569 GeneCards: PCSK6
Gene location (Human) Chr. Chromosome 15 (human) Band n/a Start 101,297,142 bp End 101,525,202 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band n/a Start 65,861,734 bp End 66,050,386 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • heparin binding • nerve growth factor binding • peptidase activity • serine-type peptidase activity • serine-type endopeptidase activity • hydrolase activity • endopeptidase activity Cellular component • membrane • extracellular matrix • cell surface • endoplasmic reticulum • Golgi lumen • endomembrane system • extracellular region • extracellular space • plasma Biological process • glycoprotein metabolic process • secretion by cell • protein processing • proteolysis • regulation of BMP signaling pathway • determination of left/right symmetry • peptide hormone processing • zygotic determination of anterior/posterior axis, embryo • nerve growth factor processing • nerve growth factor production • cornification • regulation of lipoprotein lipase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5046	18553
Ensembl	ENSG00000140479	ENSMUSG00000030513
UniProt	P29122	n/a
RefSeq (mRNA)	NM_138325 NM_001291309 NM_002570 NM_138319 NM_138320 NM_138321 NM_138322 NM_138323 NM_138324	NM_001291184 NM_011048
RefSeq (protein)	NP_001278238 NP_002561 NP_612192 NP_612195 NP_612196 NP_612197 NP_612198	n/a
Location (UCSC)	Chr 15: 101.3 – 101.53 Mb	Chr 15: 65.86 – 66.05 Mb
PubMed search

5046

18553

ENSG00000140479

ENSMUSG00000030513

P29122

n/a

NM_138321
NM_138322
NM_138323
NM_138324

NM_001291184
NM_011048

NP_612197
NP_612198

n/a

Proprotein convertase subtilisin/kexin type 6 is an enzyme that in humans is encoded by the PCSK6 gene.PCSK6 is a protease that cleaves NODAL into an active form to help trigger the development of left/right (LR) asymmetry. It may also be involved in left and right handedness in humans.

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. Alternatively spliced transcript variants encoding different isoforms have been identified.

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Wikipedia