NODAL

NODAL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4N1D
Identifiers
Aliases	NODAL, HTX5, nodal growth differentiation factor
External IDs	MGI: 97359 HomoloGene: 8417 GeneCards: NODAL
Gene ontology Molecular function • receptor agonist activity • cytokine activity • type I activin receptor binding • morphogen activity • transforming growth factor beta receptor binding • growth factor activity Cellular component • extracellular region • extracellular space Biological process • trophectodermal cellular morphogenesis • left lung morphogenesis • nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry • neural fold formation • maternal process involved in parturition • cell fate commitment • endoderm development • transforming growth factor beta receptor signaling pathway involved in primitive streak formation • floor plate morphogenesis • endodermal cell differentiation • epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification • SMAD protein signal transduction • embryonic pattern specification • polarity specification of proximal/distal axis • positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry • digestive system development • positive regulation of cell-cell adhesion • lung development • positive regulation of epithelial cell proliferation • placenta development • negative regulation of cell differentiation • positive regulation of pathway-restricted SMAD protein phosphorylation • mesoderm formation • negative regulation of androgen receptor signaling pathway • gastrulation with mouth forming second • anatomical structure formation involved in morphogenesis • positive regulation of sequence-specific DNA binding transcription factor activity • regulation of stem cell population maintenance • formation of anatomical boundary • embryonic placenta development • in utero embryonic development • negative regulation of transcription from RNA polymerase II promoter • negative regulation of trophoblast cell migration • tissue morphogenesis • BMP signaling pathway • nervous system development • positive regulation of angiogenesis • embryonic heart tube development • nodal signaling pathway • stem cell population maintenance • multicellular organism development • heart looping • embryonic process involved in female pregnancy • heart development • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • brain development • axial mesodermal cell fate specification • vasculature development • positive regulation of activin receptor signaling pathway • determination of left/right symmetry • maternal placenta development • regulation of signal transduction • gastrulation • trophectodermal cell differentiation • mesendoderm development • positive regulation of cell proliferation • positive regulation of ERK1 and ERK2 cascade • embryonic cranial skeleton morphogenesis • liver development • positive regulation of vascular endothelial growth factor production • cell migration involved in gastrulation • negative regulation of chorionic trophoblast cell proliferation • anterior/posterior axis specification • cell migration • regulation of gastrulation • primitive streak formation • negative regulation of cell development • positive regulation of transcription from RNA polymerase II promoter • digestive tract morphogenesis • positive regulation of SMAD protein import into nucleus • anterior/posterior pattern specification • inhibition of neuroepithelial cell differentiation • cell development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4838	18119
Ensembl	ENSG00000156574	ENSMUSG00000037171
UniProt	Q96S42	P43021
RefSeq (mRNA)	NM_018055 NM_001329906	NM_013611
RefSeq (protein)	NP_001316835 NP_060525	NP_038639.2 NP_038639
Location (UCSC)	Chr 10: 70.43 – 70.45 Mb	Chr 10: 61.42 – 61.43 Mb
PubMed search

4N1D

4838

18119

ENSG00000156574

ENSMUSG00000037171

Q96S42

P43021

NM_018055
NM_001329906

NM_013611

NP_001316835
NP_060525

NP_038639.2
NP_038639

Nodal is a secretory protein that in humans is encoded by the NODAL gene which is located on chromosome 10q22.1. It belongs to the Transforming Growth Factor (TGF-β) superfamily. Like many other members of this superfamily it is involved in cell differentiation in early embryogenesis, playing a key role in signal transfer from the node, in the anterior primitive streak, to lateral plate mesoderm (LPM).

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