PAPOLA

Identifiers

PAPOLA, PAP, poly(A) polymerase alpha

External IDs

Gene ontology
Molecular function	• transferase activity • nucleotide binding • nucleotidyltransferase activity • manganese ion binding • metal ion binding • protein binding • RNA binding • ATP binding • magnesium ion binding • polynucleotide adenylyltransferase activity
Cellular component	• cytoplasm • nucleoplasm • nucleus
Biological process	• mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • RNA 3'-end processing • mRNA processing • mRNA polyadenylation • mRNA 3'-end processing • regulation of mRNA 3'-end processing • RNA polyadenylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10914


18789


ENSG00000090060


ENSMUSG00000021111


P51003


Q61183

RefSeq (mRNA)

NM_001252006 NM_001252007 NM_001293627 NM_001293628 NM_001293632
NM_032632


NM_011112 NM_001347440

RefSeq (protein)

NP_001238935 NP_001238936 NP_001280556 NP_001280557 NP_001280561
NP_116021


NP_001334369 NP_035242

Location (UCSC)

PubMed search

Poly(A) polymerase alpha is an enzyme that in humans is encoded by the PAPOLA gene.

PAPOLA binds to FIP1L1 (Factor interacting with PAPOLA and CPSF1), a subunit of the cleavage and polyadenylation specificity factor subunit 1 (CPSF1) complex. This complex polyadenylates the 3' end of precursor mRNAs (pre-mRNA) (see CPSF). CPSF1 is an RNA processing protein that binds to uracil-rich sequences in pre-mRNA, binds with and stimulates POPOLA's Polynucleotide adenylyltransferase activity, and thereby adds adenylyl residues to pre-mRNA. This poly-adenylyl action increases pre mRNA's maturation and movement from the nucleus to cytoplasm while dramatically increasing the stability of the mRNA formed from pre-mRNA: FIP1L1 is a Pre-mRNA 3'-end-processing factor. FIP1L1 gene fusions between it and either the platelet-derived growth factor receptor, alpha (PGDFRA) or Retinoic acid receptor alpha (RARA) genes are causes of certain human diseases associated with pathologically increased levels of blood eosinophils and/or Leukemias.