Retinoic acid receptor alpha

RARA

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1DKF, 1DSZ, 3A9E, 3KMR, 3KMZ, 4DQM, 5K13

Identifiers

Aliases

RARA, NR1B1, RAR, retinoic acid receptor alpha

External IDs

MGI: 97856 HomoloGene: 20262 GeneCards: RARA

Targeted by Drug

adapalene, alitretinoin, tamibarotene, tazarotene, tretinoin

Gene ontology
Molecular function	• retinoic acid binding • transcription corepressor activity • protein domain specific binding • transcription factor activity, sequence-specific DNA binding • histone deacetylase binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • transcription regulatory region DNA binding • mRNA 5'-UTR binding • receptor binding • RNA polymerase II regulatory region sequence-specific DNA binding • retinoic acid-responsive element binding • transcription factor binding • metal ion binding • steroid hormone receptor activity • enzyme binding • retinoic acid receptor activity • zinc ion binding • protein binding • drug binding • DNA binding • sequence-specific DNA binding • transcription coactivator activity • protein kinase A binding • protein kinase B binding • translation repressor activity, nucleic acid binding • regulatory region DNA binding • alpha-actinin binding • protein heterodimerization activity • chromatin DNA binding • RNA polymerase II regulatory region DNA binding
Cellular component	• cytoplasm • actin cytoskeleton • perinuclear region of cytoplasm • neuron projection • nucleus • cell surface • nuclear chromatin • nucleoplasm • neuronal cell body • dendrite • cytosol
Biological process	• growth plate cartilage development • germ cell development • cellular response to retinoic acid • ureteric bud development • positive regulation of interleukin-5 production • prostate gland development • limb development • apoptotic cell clearance • chondroblast differentiation • regulation of granulocyte differentiation • protein phosphorylation • response to vitamin A • face development • spermatogenesis • response to ethanol • negative regulation of cell proliferation • steroid hormone mediated signaling pathway • regulation of apoptotic process • response to cytokine • negative regulation of translation • regulation of transcription, DNA-templated • negative regulation of cell differentiation • negative regulation of gene expression • transcription, DNA-templated • cellular response to estrogen stimulus • positive regulation of transcription, DNA-templated • positive regulation of cell cycle • regulation of myelination • positive regulation of neuron differentiation • negative regulation of tumor necrosis factor production • transcription initiation from RNA polymerase II promoter • trachea cartilage development • glandular epithelial cell development • male gonad development • negative regulation of cartilage development • response to retinoic acid • negative regulation of granulocyte differentiation • multicellular organism growth • female pregnancy • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • positive regulation of interleukin-4 production • regulation of synaptic plasticity • outflow tract septum morphogenesis • negative regulation of transcription, DNA-templated • negative regulation of interferon-gamma production • response to estradiol • negative regulation of translational initiation • embryonic camera-type eye development • positive regulation of interleukin-13 production • neural tube closure • positive regulation of binding • retinoic acid receptor signaling pathway • positive regulation of gene expression • Sertoli cell fate commitment • positive regulation of cell proliferation • positive regulation of T-helper 2 cell differentiation • ventricular cardiac muscle cell differentiation • liver development • cellular response to lipopolysaccharide • bone development • hippocampus development • signal transduction • positive regulation of transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5914


19401

Ensembl


ENSG00000131759


ENSMUSG00000037992

UniProt


P10276 Q6I9R7


P11416

RefSeq (mRNA)


NM_000964 NM_001024809 NM_001033603 NM_001145301 NM_001145302


NM_001176528 NM_001177302 NM_001177303 NM_009024

RefSeq (protein)

NP_000955 NP_001019980 NP_001138773 NP_001138774 NP_000955.1
NP_001138773.1

NP_001169999.1 NP_001170773.1 NP_001170774.1 NP_033050.2 NP_001169999
NP_001170773 NP_001170774 NP_033050

Location (UCSC)

Chr 17: 40.31 – 40.36 Mb

Chr 11: 98.93 – 98.97 Mb

PubMed search

1DKF, 1DSZ, 3A9E, 3KMR, 3KMZ, 4DQM, 5K13

NM_000964
NM_001024809
NM_001033603
NM_001145301
NM_001145302

NM_001176528
NM_001177302
NM_001177303
NM_009024

...
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