FIP1L1

Identifiers

FIP1L1, FIP1, Rhe, hFip1, factor interacting with PAPOLA and CPSF1

External IDs

Gene ontology
Molecular function	• protein binding • RNA binding
Cellular component	• nucleus • nucleoplasm • mRNA cleavage and polyadenylation specificity factor complex
Biological process	• mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA processing • mRNA 3'-end processing • mRNA export from nucleus • mRNA polyadenylation • pre-mRNA cleavage required for polyadenylation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


81608


n/a

Ensembl


ENSG00000145216


n/a

UniProt


Q6UN15


n/a

RefSeq (mRNA)


NM_001134937 NM_001134938 NM_030917


n/a

RefSeq (protein)


NP_001128409 NP_001128410 NP_112179


n/a

Location (UCSC)

Chr 4: 53.38 – 53.46 Mb

n/a

PubMed search

n/a

81608

n/a

ENSG00000145216

n/a

Q6UN15

n/a

NM_001134937
NM_001134938
NM_030917

n/a

NP_001128409
NP_001128410
NP_112179

n/a

Factor interacting with PAPOLA and CPSF1 (i.e, FIP1L1; also termed Pre-mRNA 3'-end-processing factor FIP1) is a protein that in humans is encoded by the FIP1L1 gene (also known as Rhe, FIP1, and hFip1). An medically important aspect of the FIP1L1 gene is its fusion with other genes to form fusion genes which cause hypereosinophilia and leukemic diseases in humans.

The human FIP1L1 gene is located on chromosome 4 at position q12 (4q12), contains 19 exons, and codes for a complete protein consisting of 594 amino acids. However, alternative splicing of its Precursor mRNA results in multiple transcript variants encoding distinct FIP1L1 protein isoforms. The FIP1L1 gene is found in a wide range of species, being designated as FIP1 in Saccharomyces cerevisiae (yeast) and fip1l1 in coho salmon as well as mice and numerous other mammalian species.

...
Wikipedia