Orghana (Orakina or Ergene Khatun) was an Oirat princess of the Mongol Empire and Empress of the Chagatai Khanate. She was a descendant of Qutuqi Beki, chief of the Oirats and Checheyikhen, daughter of Genghis Khan.
She married Qara Hülëgü, a grandson of Chagatai Khan. Her husband was enthroned as Chagatayid Khan in 1242 after deaths of both Ögedei and Chagatai. However, Güyük Khan replaced Qara Hulagu with his uncle Yesü Möngke in 1246.
When the Toluid family overthrew the Ögedeids, Qara Hulagu supported Möngke Khan in 1251. Möngke reappointed Qara Hulagu khan of the Chagatai Khanate and executed Yesü Möngke. However, he died on the way and Möngke permitted his widow Orghana to serve as regent in the name of her infant son. She ruled the Khanate from 1252 to 1261, nine years.
According to Rashid al-Din, she organized a banquet for Hulagu when his army was marching through Central Asia to Iran in 1255.
In 1260, the Toluid Civil War broke out in the Mongol Empire with the death of Möngke, and his brother Ariq Böke dispatched Alghu to Beshbalik to consolidate his power. Alghu removed Orghana from power whereupon she fled to Mongolia. Taking advantage of the struggle between Ariq Böke and the older brother Kublai, Alghu acted as an autonomous khan who sided with Kublai and killed Ariq Böke's officials. After several battles, Ariq Böke sent Masud Beg and Orghana to Alghu to negotiate peace.