Yesü Möngke (died 1252) was head of the ulus of the Chagatai Khanate (1246 or 1247-1252). He was the son of Chagatai Khan.
In or around 1246, he was appointed as khan of the Chagatai Khanate by his cousin the Great Khan Güyük Khan, whom he was friends with, following the deposition of Qara Hülëgü. The next Great Khan, however, Möngke Khan, initiated a purge of the supporters of the house of Ögedei Khan, amongst which were the Chaghadaids. Yesü Möngke and the Chaghadaid prince Büri were both exiled by Möngke to the camp of Batu Khan of the Blue Horde, who executed them. Qara Hülëgü was then restored to his former position.