OATP1B1

SLCO1B1
Identifiers
Aliases	SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6, solute carrier organic anion transporter family member 1B1
External IDs	HomoloGene: 74575 GeneCards: SLCO1B1
Targeted by Drug
cyclosporine, estrone sulfate, gemfibrozil, glycyrrhizin, , pravastatin
Gene ontology Molecular function • transporter activity • sodium-independent organic anion transmembrane transporter activity • thyroid hormone transmembrane transporter activity • bile acid transmembrane transporter activity Cellular component • integral component of membrane • plasma membrane • basolateral plasma membrane • integral component of plasma membrane • membrane Biological process • ion transport • bile acid and bile salt transport • organic anion transport • transport • thyroid hormone transport • sodium-independent organic anion transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10599	n/a
Ensembl	ENSG00000134538	n/a
UniProt	Q9Y6L6	n/a
RefSeq (mRNA)	NM_006446	n/a
RefSeq (protein)	NP_006437	n/a
Location (UCSC)	Chr 12: 21.13 – 21.24 Mb	n/a
PubMed search		n/a

10599

n/a

ENSG00000134538

n/a

Q9Y6L6

n/a

NM_006446

n/a

NP_006437

n/a

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene.Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin. Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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