New York State Route 80

New York State Route 80
Map of central New York with NY 80 highlighted in red
Route information
Maintained by NYSDOT, Madison County, the city of Syracuse, and the village of Cooperstown
Length:	127.32 mi (204.90 km)
Existed:	late 1920s – present
Major junctions
West end:	NY 175 in Syracuse
	US 20 in Onondaga I-81 in Tully NY 13 in NY 26 in Georgetown, Otselic NY 12 in Sherburne NY 8 in New Berlin NY 28 in Cooperstown, Oaksville US 20 in Springfield
East end:	NY 5 in Nelliston
Location
Counties:	Montgomery, Herkimer, Otsego, Chenango, Madison, Onondaga
Highway system
New York Highways Interstate U.S. State Reference Parkways ← NY 79 I-81 →

New York State Route 80 (NY 80) is a west–east New York State Route located within Onondaga, Madison, Chenango, Otsego, Herkimer, and Montgomery counties in New York. Its western terminus is located at a junction with NY 175 in the city of Syracuse in Onondaga County, from which it actually runs in a north–south direction for 20 miles (32 km). The eastern terminus is located at a junction with NY 5 in the village of Nelliston in Montgomery County. The route is signed north–south within Montgomery County.

Most of NY 80 between Sherburne and Cooperstown follows the routing of the Second Great Western Turnpike, a 19th-century toll road.

Although NY 80 follows an east–west alignment for most of its routing, two sections, located on its western and easternmost ends, are either signed as north–south (as is the case in Montgomery County) or physically oriented from north to south (such as in central Onondaga County).