NK1.1

KLRB1
Identifiers
Aliases	KLRB1, CD161, CLEC5B, NKR, NKR-P1, NKR-P1A, NKRP1A, hNKR-P1A, killer cell lectin like receptor B1
External IDs	MGI: 107538 HomoloGene: 84369 GeneCards: KLRB1
Gene ontology Molecular function • transmembrane signaling receptor activity • carbohydrate binding Cellular component • integral component of membrane • plasma membrane • membrane Biological process • cell surface receptor signaling pathway • regulation of immune response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3820	17059
Ensembl	ENSG00000111796	ENSMUSG00000030325
UniProt	Q12918	P27814
RefSeq (mRNA)	NM_002258	NM_001159904 NM_008527
RefSeq (protein)	NP_002249	NP_001153376.1 NP_032553.2 NP_001153376 NP_032553
Location (UCSC)	Chr 12: 9.59 – 9.61 Mb	Chr 6: 128.78 – 128.79 Mb
PubMed search

3820

17059

ENSG00000111796

ENSMUSG00000030325

Q12918

P27814

NM_002258

NM_001159904
NM_008527

NP_002249

NP_001153376.1
NP_032553.2
NP_001153376
NP_032553

Killer cell lectin-like receptor subfamily B, member 1, also known as NK1.1,KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene.

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus. NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.

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Wikipedia