CLEC2D

CLEC2D
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4QKG, 4QKH, 4QKI, 4QKJ, 4WCO
Identifiers
Aliases	CLEC2D, CLAX, LLT1, OCIL, C-type lectin domain family 2 member D
External IDs	HomoloGene: 137257 GeneCards: CLEC2D
Gene ontology Molecular function • transmembrane signaling receptor activity • carbohydrate binding • protein binding Cellular component • plasma membrane • membrane • cell surface • integral component of membrane • endoplasmic reticulum • integral component of plasma membrane Biological process • regulation of immune response • cell surface receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29121	n/a
Ensembl	ENSG00000069493	n/a
UniProt	Q9UHP7	n/a
RefSeq (mRNA)	NM_001004419 NM_001004420 NM_001197317 NM_001197318 NM_001197319 NM_013269	n/a
RefSeq (protein)	NP_001004419 NP_001184246 NP_001184247 NP_001184248 NP_037401	n/a
Location (UCSC)	Chr 12: 9.66 – 9.7 Mb	n/a
PubMed search		n/a

4QKG, 4QKH, 4QKI, 4QKJ, 4WCO

29121

n/a

ENSG00000069493

n/a

Q9UHP7

n/a

NM_013269

n/a

NP_001004419
NP_001184246
NP_001184247
NP_001184248
NP_037401

n/a

C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene.

This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified, but the full-length nature of every transcript has not been defined. CLEC2D encodes the gene for the Lectin Like Transcript-1 (LLT1) protein which is a functional ligand for the human NKR-P1A receptor, encoded by the KLRB1 gene. In mice, there are many orthologs of the CLEC2D gene, and the presumed homolog is Clr-b/Ocil (Clec2d). Clr-b has been implicated in missing-self recognition by natural killer cells through engagement of the NKR-P1B receptor.

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