Muscarinic acetylcholine receptor M4

CHRM4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5DSG
Identifiers
Aliases	CHRM4, HM4, M4R, cholinergic receptor muscarinic 4
External IDs	MGI: 88399 HomoloGene: 20192 GeneCards: CHRM4
Targeted by Drug
acetylcholine, arecoline, bethanechol, milameline, pilocarpine, sabcomeline, xanomeline, brucine, staurosporine, vinburnine, vincamine, AFDX384, amitriptyline, biperiden, darifenacin, glycopyrrolate, hexocyclium, himbacine, methoctramine free base, oxybutynin, pirenzepine, propantheline, 3-quinuclidinyl-benzilate, tolterodine, , oxotremorine
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • G-protein coupled acetylcholine receptor activity Cellular component • integral component of membrane • postsynaptic membrane • membrane • plasma membrane • synapse • integral component of plasma membrane • cell junction Biological process • G-protein coupled acetylcholine receptor signaling pathway • G-protein coupled receptor signaling pathway • regulation of locomotion • synaptic transmission, cholinergic • cell surface receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway • phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway • cell proliferation • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1132	12672
Ensembl	ENSG00000180720	ENSMUSG00000040495
UniProt	P08173	P32211
RefSeq (mRNA)	NM_000741	NM_007699
RefSeq (protein)	NP_000732	NP_031725.1 NP_031725
Location (UCSC)	Chr 11: 46.39 – 46.39 Mb	Chr 2: 91.93 – 91.93 Mb
PubMed search

5DSG

1132

12672

ENSG00000180720

ENSMUSG00000040495

P08173

P32211

NM_000741

NM_007699

NP_000732

NP_031725.1
NP_031725

The muscarinic acetylcholine receptor M₄, also known as the cholinergic receptor, muscarinic 4 (CHRM4), is a protein that, in humans, is encoded by the CHRM4 gene.

M₄muscarinic receptors are coupled to G_i/o heterotrimeric proteins.

They function as inhibitory autoreceptors for acetylcholine. Activation of M₄ receptors inhibits acetylcholine release in the striatum. The M₂ subtype of acetylcholine receptor functions similarly as an inhibitory autoreceptor to acetylcholine release, albeit functioning actively primarily in the hippocampus and cerebral cortex.

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Wikipedia