Msh homeobox 2

MSX2
Identifiers
Aliases	MSX2, CRS2, FPP, HOX8, MSH, PFM, PFM1, Msh homeobox 2
External IDs	MGI: 97169 HomoloGene: 1837 GeneCards: MSX2
Gene location (Human) Chr. Chromosome 5 (human) Band 5q35.2 Start 174,724,533 bp End 174,730,893 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 B1|13 27.84 cM Start 53,466,884 bp End 53,473,074 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • transcription cofactor activity • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • RNA polymerase II regulatory region sequence-specific DNA binding • protein binding • transcription factor activity, transcription factor binding • transcription regulatory region DNA binding • transcription factor binding Cellular component • nucleus • cytosol • nuclear speck Biological process • negative regulation of cell proliferation • positive regulation of timing of catagen • negative regulation of keratinocyte differentiation • negative regulation of transcription regulatory region DNA binding • embryonic limb morphogenesis • frontal suture morphogenesis • mammary gland epithelium development • BMP signaling pathway involved in heart development • enamel mineralization • ossification • anterior/posterior pattern specification • bone morphogenesis • regulation of transcription, DNA-templated • cellular response to growth factor stimulus • activation of meiosis • endochondral bone growth • wound healing, spreading of epidermal cells • BMP signaling pathway • embryonic digit morphogenesis • positive regulation of mesenchymal cell apoptotic process • multicellular organism development • embryonic hindlimb morphogenesis • negative regulation of CREB transcription factor activity • outflow tract morphogenesis • bone trabecula formation • wound healing • regulation of apoptotic process • chondrocyte development • osteoblast development • positive regulation of osteoblast differentiation • cranial suture morphogenesis • negative regulation of fat cell differentiation • branching involved in mammary gland duct morphogenesis • outflow tract septum morphogenesis • negative regulation of transcription, DNA-templated • osteoblast differentiation • epithelial to mesenchymal transition involved in endocardial cushion formation • positive regulation of BMP signaling pathway • signal transduction involved in regulation of gene expression • cellular response to estradiol stimulus • embryonic forelimb morphogenesis • embryonic nail plate morphogenesis • negative regulation of apoptotic process • cartilage development • stem cell differentiation • odontogenesis • transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4488	17702
Ensembl	ENSG00000120149	ENSMUSG00000021469
UniProt	P35548	Q03358
RefSeq (mRNA)	NM_002449	NM_013601
RefSeq (protein)	NP_002440	NP_038629
Location (UCSC)	Chr 5: 174.72 – 174.73 Mb	Chr 5: 53.47 – 53.47 Mb
PubMed search

4488

17702

ENSG00000120149

ENSMUSG00000021469

P35548

Q03358

NM_002449

NM_013601

NP_002440

NP_038629

Homeobox protein MSX-2 is a protein that in humans is encoded by the MSX2 gene.

This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2.

Msh homeobox 2 has been shown to interact with DLX5,DLX2 and MSX1.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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