DLX5

DLX5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DJN, 4RDU
Identifiers
Aliases	DLX5, SHFM1D, AI385752, distal-less homeobox 5
External IDs	MGI: 101926 HomoloGene: 3825 GeneCards: DLX5
Gene location (Human) Chr. Chromosome 7 (human) Band 7q21.3 Start 97,020,392 bp End 97,025,097 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 A1|6 2.83 cM Start 6,877,805 bp End 6,882,085 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • HMG box domain binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcription regulatory region DNA binding Cellular component • cytoplasm • nuclear chromatin • nucleus Biological process • skeletal system development • palate development • regulation of transcription, DNA-templated • epithelial cell differentiation • axonogenesis • ossification • positive regulation of epithelial cell proliferation • positive regulation of canonical Wnt signaling pathway • anatomical structure formation involved in morphogenesis • bone morphogenesis • head development • cellular response to BMP stimulus • ear development • endochondral ossification • transcription from RNA polymerase II promoter • BMP signaling pathway • olfactory pit development • transcription, DNA-templated • nervous system development • axon guidance • positive regulation of transcription, DNA-templated • multicellular organism development • embryonic limb morphogenesis • inner ear morphogenesis • osteoblast differentiation • cell proliferation • face morphogenesis • positive regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus • positive regulation of gene expression • olfactory bulb interneuron differentiation • interneuron axon guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1749	13395
Ensembl	ENSG00000105880	ENSMUSG00000029755
UniProt	P56178	P70396
RefSeq (mRNA)	NM_005221	NM_010056 NM_198854
RefSeq (protein)	NP_005212	NP_034186 NP_942151
Location (UCSC)	Chr 7: 97.02 – 97.03 Mb	Chr 7: 6.88 – 6.88 Mb
PubMed search

2DJN, 4RDU

1749

13395

ENSG00000105880

ENSMUSG00000029755

P56178

P70396

NM_005221

NM_010056
NM_198854

NP_005212

NP_034186
NP_942151

Homeobox protein DLX-5 is a protein that in humans is encoded by the distal-less homeobox 5 gene, or DLX5 gene. DLX5 is a member of DLX gene family.

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less (Dll) gene. The encoded protein may play a role in bone development and fracture healing. Current research holds that the homeobox gene family is important in appendage development. DLX5 and DLX6 can be seen to work in conjunction and are both necessary for proper craniofacial, axial, and appendicular skeleton development. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.

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Wikipedia