DLX2

DLX2
Identifiers
Aliases	DLX2, TES-1, TES1, AW121999, Dlx-2, distal-less homeobox 2
External IDs	MGI: 94902 HomoloGene: 3244 GeneCards: DLX2
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • chromatin binding • protein binding • single-stranded RNA binding Cellular component • nucleus Biological process • cerebral cortex GABAergic interneuron differentiation • proximal/distal pattern formation • cell differentiation • regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • branching morphogenesis of a nerve • embryonic skeletal system development • multicellular organism development • odontogenesis of dentin-containing tooth • cerebral cortex GABAergic interneuron fate commitment • cartilage development • brain development • negative regulation of oligodendrocyte differentiation • forebrain neuron differentiation • embryonic cranial skeleton morphogenesis • olfactory bulb development • hippocampus development • subpallium development • negative regulation of Notch signaling pathway • positive regulation of transcription from RNA polymerase II promoter • positive regulation of cell differentiation • negative regulation of photoreceptor cell differentiation • positive regulation of amacrine cell differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1746	13392
Ensembl	ENSG00000115844	ENSMUSG00000023391
UniProt	Q07687	P40764
RefSeq (mRNA)	NM_004405	NM_010054
RefSeq (protein)	NP_004396 NP_004396.1	NP_034184.1 NP_034184
Location (UCSC)	Chr 2: 172.1 – 172.1 Mb	Chr 2: 71.54 – 71.55 Mb
PubMed search

1746

13392

ENSG00000115844

ENSMUSG00000023391

Q07687

P40764

NM_004405

NM_010054

NP_004396
NP_004396.1

NP_034184.1
NP_034184

Homeobox protein DLX-2 is a protein that in humans is encoded by the DLX2 gene.

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.

DLX2 has been shown to interact with DLX5,MSX1 and Msh homeobox 2.

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