Moesin

MSN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E5W, 1EF1, 1SGH
Identifiers
Aliases	MSN, HEL70, moesin, IMD50
External IDs	MGI: 97167 HomoloGene: 1833 GeneCards: MSN
Gene ontology Molecular function • cytoskeletal protein binding • structural constituent of cytoskeleton • protein binding • actin binding • double-stranded RNA binding • receptor binding • protein kinase binding • cell adhesion molecule binding • enzyme binding Cellular component • cytoplasm • vesicle • cell projection • pseudopodium • blood microparticle • membrane • focal adhesion • filopodium • myelin sheath • plasma membrane • apical part of cell • microvillus • uropod • basolateral plasma membrane • apical plasma membrane • perinuclear region of cytoplasm • extracellular exosome • cytoskeleton • microvillus membrane • nucleus • cell periphery • extracellular space • cell surface • invadopodium • cytosol Biological process • leukocyte cell-cell adhesion • regulation of cell size • establishment of endothelial barrier • movement of cell or subcellular component • regulation of organelle assembly • positive regulation of cellular protein catabolic process • cellular response to testosterone stimulus • regulation of lymphocyte migration • positive regulation of podosome assembly • gland morphogenesis • positive regulation of gene expression • establishment of epithelial cell apical/basal polarity • regulation of cell shape • membrane to membrane docking • positive regulation of protein localization to early endosome • positive regulation of early endosome to late endosome transport • leukocyte migration • cytoskeleton organization • immunological synapse formation • T cell proliferation • T cell aggregation • T cell migration • interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4478	17698
Ensembl	ENSG00000147065	ENSMUSG00000031207
UniProt	P26038	P26041
RefSeq (mRNA)	NM_002444	NM_010833
RefSeq (protein)	NP_002435	NP_034963
Location (UCSC)	Chr X: 65.59 – 65.74 Mb	Chr X: 96.1 – 96.17 Mb
PubMed search

1E5W, 1EF1, 1SGH

4478

17698

ENSG00000147065

ENSMUSG00000031207

P26038

P26041

NM_002444

NM_010833

NP_002435

NP_034963

Moesin is a protein that in humans is encoded by the MSN gene.

Moesin (for membrane-organizing extension spike protein) is a member of the ERM protein family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons.

Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement.

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Wikipedia