Ezrin

EZR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RM8, 4RMA, 4RM9, 1NI2
Identifiers
Aliases	EZR, CVIL, CVL, HEL-S-105, VIL2, Ezrin
External IDs	MGI: 98931 HomoloGene: 55740 GeneCards: EZR
Gene ontology Molecular function • protein domain specific binding • protein complex binding • cytoskeletal protein binding • protein kinase A regulatory subunit binding • protein kinase A catalytic subunit binding • S100 protein binding • actin filament binding • protein binding • cell adhesion molecule binding • microtubule binding • ATPase binding • actin binding • RNA binding • cadherin binding • protein C-terminus binding • disordered domain specific binding Cellular component • cytoplasm • cytosol • endosome • membrane • focal adhesion • T-tubule • ruffle • Schwann cell microvillus • ruffle membrane • actin cytoskeleton • perinuclear region of cytoplasm • cytoskeleton • cell projection • cytoplasmic side of apical plasma membrane • myelin sheath • microvillus • microspike • apical plasma membrane • membrane raft • extracellular exosome • microvillus membrane • ciliary basal body • filopodium • cortical cytoskeleton • plasma membrane • apical part of cell • astrocyte projection • intracellular • cell cortex • brush border • actin filament • TCR signalosome • cell periphery • cell body • vesicle • plasma membrane raft • uropod • basolateral plasma membrane • immunological synapse • cell tip • fibrillar center • extracellular space • extrinsic component of membrane • invadopodium Biological process • leukocyte cell-cell adhesion • regulation of organelle assembly • sphingosine-1-phosphate signaling pathway • negative regulation of p38MAPK cascade • actin filament bundle assembly • establishment of epithelial cell apical/basal polarity • cytoskeletal anchoring at plasma membrane • positive regulation of multicellular organism growth • astral microtubule organization • cellular response to cAMP • establishment of endothelial barrier • microvillus assembly • positive regulation of cellular protein catabolic process • negative regulation of T cell receptor signaling pathway • positive regulation of establishment of protein localization to plasma membrane • gland morphogenesis • cortical microtubule organization • positive regulation of protein localization to early endosome • positive regulation of early endosome to late endosome transport • intestinal D-glucose absorption • establishment or maintenance of apical/basal cell polarity • regulation of NIK/NF-kappaB signaling • epithelial cell differentiation • regulation of actin cytoskeleton organization • negative regulation of interleukin-2 secretion • negative regulation of transcription from RNA polymerase II promoter • positive regulation of protein secretion • membrane to membrane docking • regulation of cell shape • protein kinase A signaling • establishment of centrosome localization • phosphatidylinositol-mediated signaling • regulation of cell size • actin cytoskeleton reorganization • filopodium assembly • receptor internalization • terminal web assembly • axon guidance • positive regulation of gene expression • cellular protein complex localization • negative regulation of ERK1 and ERK2 cascade • establishment of protein localization to plasma membrane • protein localization to cell cortex • regulation of microvillus length Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7430	22350
Ensembl	ENSG00000092820	ENSMUSG00000052397
UniProt	P15311	P26040
RefSeq (mRNA)	NM_001111077 NM_003379	NM_009510
RefSeq (protein)	NP_001104547 NP_003370	NP_033536.2 NP_033536
Location (UCSC)	Chr 6: 158.77 – 158.82 Mb	Chr 17: 6.74 – 6.78 Mb
PubMed search

4RM8, 4RMA, 4RM9, 1NI2

7430

22350

ENSG00000092820

ENSMUSG00000052397

P15311

P26040

NM_001111077
NM_003379

NM_009510

NP_001104547
NP_003370

NP_033536.2
NP_033536

Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene.

The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain.

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