The Middle Moselle or Central Moselle (German: Mittelmosel) refers to the approximately 120-kilometre-long section of the river Moselle, in the state of Rhineland-Palatinate in Germany from the city of Trier to Zell. The subsequent section of the river to its mouth, where it flows into the Rhine, is known as the Lower Moselle.
The Central Moselle landscape is formed by the many meanders of the river, between the Hunsrück and the Eifel highlands in a deep valley with steep slopes on which the grapes for the Mosel wine are grown. The river follows an exceptionally beautiful scenic route. There are a number of well-known wine and tourist destinations in the Mittelmosel including Schweich, Longuich, Mehring, Klüsserath, Trittenheim, Neumagen-Dhron, Piesport, Brauneberg-Filzen, Bernkastel-Kues, Zeltingen-Rachtig, Kröv, Traben-Trarbach, Reil and Zell.
The Central Moselle has been a winegrowing region since the days of the Romans. The Romans used the Moselle even then for transportation of the wines produced there.