Melatonin receptor 2

MTNR1B
Identifiers
Aliases	MTNR1B, FGQTL2, MEL-1B-R, MT2, Melatonin receptor 1B
External IDs	MGI: 2181726 HomoloGene: 4350 GeneCards: MTNR1B
Genetically Related Diseases
type 2 diabetes mellitus
Targeted by Drug
6-hydroxymelatonin, agomelatine, GR 196429, ly-156735, melatonin, ramelteon, tasimelteon, luzindole
Gene ontology Molecular function • signal transducer activity • melatonin receptor activity • protein binding • G-protein coupled receptor activity Cellular component • integral component of membrane • membrane • integral component of plasma membrane • plasma membrane Biological process • G-protein coupled receptor signaling pathway • glucose homeostasis • regulation of insulin secretion • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • circadian rhythm • signal transduction • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4544	244701
Ensembl	ENSG00000134640	ENSMUSG00000050901
UniProt	P49286	Q8CIQ6
RefSeq (mRNA)	NM_005959	NM_145712
RefSeq (protein)	NP_005950	n/a
Location (UCSC)	Chr 11: 92.97 – 92.99 Mb	Chr 9: 15.82 – 15.87 Mb
PubMed search

4544

244701

ENSG00000134640

ENSMUSG00000050901

P49286

Q8CIQ6

NM_005959

NM_145712

NP_005950

n/a

Melatonin receptor 1B, also known as MTNR1B, is a protein that in humans is encoded by the MTNR1B gene.

This gene encodes the MT₂protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain; however, this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin.

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