GR-196,429

GR-196,429

Identifiers
IUPAC name N-[2-(2,3,7,8-tetrahydrofuro[2,3-g]indol-1-yl)ethyl]acetamide
CAS Number	170729-12-1 Y
PubChem CID	5311134
IUPHAR/BPS	1349
ChemSpider	4470661 Y
Chemical and physical data
Formula	C14H18N2O2
Molar mass	246.308
3D model (JSmol)	Interactive image
SMILES c23c1CCOc1ccc2CCN3CCNC(=O)C
InChI InChI=1S/C14H18N2O2/c1-10(17)15-6-8-16-7-4-11-2-3-13-12(14(11)16)5-9-18-13/h2-3H,4-9H2,1H3,(H,15,17) Key:LTYWTNUOUBBVNZ-UHFFFAOYSA-N

GR-196,429 is a melatonin receptor agonist with some selectivity for the MT₁ subtype. It was one of the first synthetic melatonin agonists developed and continues to be used in scientific research, though it has never been developed for medical use. Studies in mice have shown GR-196,429 to produce both sleep-promoting effects and alterations of circadian rhythm, as well as stimulating melatonin release.