Melatonin receptor 1A

MTNR1A
Identifiers
Aliases	MTNR1A, MEL-1A-R, MT1, Melatonin receptor 1A
External IDs	MGI: 102967 HomoloGene: 21207 GeneCards: MTNR1A
Targeted by Drug
6-hydroxymelatonin, agomelatine, GR 196429, ly-156735, melatonin, ramelteon, tasimelteon, luzindole
Gene ontology Molecular function • hormone binding • G-protein coupled receptor activity • organic cyclic compound binding • signal transducer activity • melatonin receptor activity • protein binding Cellular component • integral component of membrane • membrane • receptor complex • integral component of plasma membrane • plasma membrane Biological process • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • positive regulation of cGMP biosynthetic process • mating behavior • cell surface receptor signaling pathway • signal transduction • circadian rhythm Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4543	17773
Ensembl	ENSG00000168412	ENSMUSG00000054764
UniProt	P48039	Q61184
RefSeq (mRNA)	NM_005958	NM_008639
RefSeq (protein)	NP_005949	NP_032665.1
Location (UCSC)	Chr 4: 186.53 – 186.56 Mb	Chr 8: 45.07 – 45.09 Mb
PubMed search

4543

17773

ENSG00000168412

ENSMUSG00000054764

P48039

Q61184

NM_005958

NM_008639

NP_005949

NP_032665.1

Melatonin receptor type 1A is a protein that in humans is encoded by the MTNR1A gene.

This gene encodes the MT₁protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G protein-coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.

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