Mato Grosso do Sul (Portuguese pronunciation: [ˈmatu ˈɡɾosu du ˈsuw]) is one of the Central-Western states of Brazil. Its total area of 357,125 square kilometers, or 137,891 square miles, is roughly the same size as Germany.

Neighboring Brazilian states are (from north clockwise) Mato Grosso, Goiás, Minas Gerais, São Paulo and Paraná. It also borders the countries of Paraguay, to the southwest, and Bolivia, to the west. The economy of the state is largely based on agriculture and cattle-raising. Crossed in the south by the Tropic of Capricorn, Mato Grosso do Sul generally has a warm, sometimes hot, and humid climate, and is crossed by numerous tributaries of the Paraná River.

The state is also famous for its natural beauty, and is a major destination for domestic and international tourism. The Pantanal lowlands cover 12 municipalities and presents an enormous variety of flora and fauna, with forests, natural sand banks, savannahs, open pasture, fields and bushes. The city Bonito, in the mountain of Bodoquena, has prehistoric caves, natural rivers, waterfalls, swimming pools and the Blue Lake cave.

The name Mato Grosso do Sul literally means "Thick Bushes of the South" in Portuguese, a name inherited from its northern neighbour state of Mato Grosso, of which it was part until the 1970s. It is not uncommon for people to mistakenly refer to Mato Grosso do Sul as simply "Mato Grosso". Other names that were proposed, at the time of the split and afterwards, include "Pantanal" (a reference to its best known geographical feature) and "Maracaju" (a reference to the Maracaju Mountain Range that crosses the state from north to south).

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