Matteo Pérez de Alesio (1547–1628) was an Italian painter of devotional, historical and maritime subjects during the Mannerist period. He was also known as Matteo da Lecce by virtue of his hometown of Lecce. He spent the majority of his entire artistic career in Peru, where he lived more than 40 years, between 1588 and 1628.
Matteo Pérez was the son of Antonio de Alessio and Madama Lucente. He was born in Lecce.
He studied under Michelangelo, working on the Sistine Chapel, in the Vatican, painting the Fall of the Angels in the facade facing Michelangelo's Last Judgment. He was a member of the Accademia di San Luca in Rome. He also painted an altarpiece for Sant'Eligio degli Orefici.
He travelled to Naples where he met the artist Pablo Moron, who became his long standing assistant. Perez's works in Rome include the fresco The Dispute over the Body of Moses (circa 1574) in the Sistine Chapel; frescoes in the Villa d'Este in Tivoli and the Villa Mondragone in Frascati. He also worked in Malta (from 1576), Seville (in the 1580s) and Lima (from 1589), where he died.
The Hall of St Michael and St George, also known as the Throne Room, of the Grandmaster's Palace, Valletta, is decorated with 13 of his frescoes showing the events of the great siege of Malta by the Turks in 1565. He is credited with having introduced mannerism to Malta with his frescoes. These were painted from 1575 to 1581, at the same time as the oil paintings of the same scene, four of which can be found in the Cube Room of the Queen's House, Greenwich, London. Among his other works in Malta there is the Baptism of Christ which was originally the titular painting of the St. John's Co-Cathedral.