Élisabeth Sophie of Lorraine (Marie Élisabeth Sophie; 1710 – 2 August 1740.) was a French noblewoman and the second wife of Armand de Vignerot du Plessis, the famous womaniser the Duke of Richelieu.

She was born in 1710 and was the second daughter of Joseph de Lorraine, Count of Harcourt and his wife Marie Louise Jeannin de Castille. Her older sister Louise Henriette Françoise married the Duke of Bouillon in 1725.

A member of the House of Guise founded by Claude, Duke of Guise, she was a Princess of Lorraine as a male line descendant of René II, Duke of Lorraine. At court, she, like his Lorraine family, held the rank of Foreign Prince, a rank which was below that of the immediate Royal Family and Princes of the Blood. This also allowed her the style of Her Highness.

Family relations included Emmanuel Maurice, Duke of Elbeuf, second cousin of her husband via Emmanuel Maurice's mother Élisabeth de La Tour d'Auvergne. Others included the Abbess of Remiremont, Princess of Epinoy and a Queen consort of Sardinia.

She was a proposed bride of Paul II Anton Esterházy, a prince of the House of Esterházy, a distinguished soldier and patron of music. The marriage never materialised.

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