Louise Henriette Françoise de Lorraine (1707 – 31 March 1737) was a French noblewoman and member of the House of Guise, a cadet branch of the House of Lorraine. She was the last wife of Emmanuel Théodose de La Tour d'Auvergne (1668–1730).

The eldest of four children, her other surviving sister Marie Elisabeth Sofie de Lorraine was the wife of Louis François Armand de Vignerot du Plessis. Prior to her marriage, she was styled as Mademoiselle de Guise.

A member of the House of Guise founded by Claude, Duke of Guise, she was a Princess of Lorraine as a patrilineal descendant of René II, Duke of Lorraine. At court, she, like his Lorraine family, held the rank of Foreign Prince, a rank which was below that of the immediate Royal Family and Princes of the Blood. This also allowed her the style of Her Highness.

Family relations included Emmanuel Maurice, Duke of Elbeuf, second cousin of her husband via Emmanuel Maurice's mother Élisabeth de La Tour d'Auvergne. Others included the Abbess of Remiremont, Princess of Epinoy and a Queen consort of Sardinia.

She was described as very pretty; rather tall than short; neither stout nor slender; an oval face; a broad forehead; black eyes and eyebrows; brown hair; very wide mouth and very red lips .

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