MAPK11

MAPK11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GC8, 3GC9, 3GP0
Identifiers
Aliases	MAPK11, P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta, mitogen-activated protein kinase 11
External IDs	MGI: 1338024 HomoloGene: 55684 GeneCards: MAPK11
Targeted by Drug
sb-203580
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • MAP kinase activity • kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding Cellular component • cytosol • nucleoplasm • nucleus • cytoplasm Biological process • cellular response to virus • intracellular signal transduction • regulation of transcription, DNA-templated • regulation of cardiac muscle cell proliferation • positive regulation of erythrocyte differentiation • phosphorylation • positive regulation of muscle cell differentiation • response to stress • transcription, DNA-templated • protein phosphorylation • positive regulation of interleukin-12 secretion • vascular endothelial growth factor receptor signaling pathway • positive regulation of gene expression • activation of MAPK activity • regulation of sequence-specific DNA binding transcription factor activity • Ras protein signal transduction • negative regulation of cardiac muscle cell proliferation • signal transduction • MAPK cascade • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5600	19094
Ensembl	ENSG00000185386	ENSMUSG00000053137
UniProt	Q15759	Q9WUI1
RefSeq (mRNA)	NM_002751	NM_011161
RefSeq (protein)	NP_002742	NP_035291.4 NP_035291
Location (UCSC)	Chr 22: 50.26 – 50.27 Mb	Chr 15: 89.14 – 89.15 Mb
PubMed search

3GC8, 3GC9, 3GP0

5600

19094

ENSG00000185386

ENSMUSG00000053137

Q15759

Q9WUI1

NM_002751

NM_011161

NP_002742

NP_035291.4
NP_035291

Mitogen-activated protein kinase 11 is an enzyme that in humans is encoded by the MAPK11 gene.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.

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Wikipedia