MKK6

MAP2K6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Y8O, 3ENM, 3FME, 3VN9
Identifiers
Aliases	MAP2K6, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3, mitogen-activated protein kinase kinase 6
External IDs	MGI: 1346870 HomoloGene: 55686 GeneCards: MAP2K6
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • kinase activity • protein binding • protein tyrosine kinase activity • ATP binding • protein kinase binding • protein serine/threonine kinase activity • MAP kinase kinase activity Cellular component • cytoplasm • nucleoplasm • cytoskeleton • nucleus • cytosol Biological process • positive regulation of protein phosphorylation • regulation of transcription, DNA-templated • cardiac muscle contraction • phosphorylation • cellular response to sorbitol • positive regulation of nitric-oxide synthase biosynthetic process • ovulation cycle process • GO:0006350 transcription, DNA-templated • MAPK cascade • protein phosphorylation • positive regulation of prostaglandin secretion • response to ischemia • activation of MAPK activity • cell cycle arrest • DNA damage induced protein phosphorylation • positive regulation of apoptotic process • peptidyl-tyrosine phosphorylation • nucleotide-binding oligomerization domain containing signaling pathway • response to drug • signal transduction • apoptotic process • proteolysis in other organism • regulation of mitotic cell cycle • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity • regulation of apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5608	26399
Ensembl	ENSG00000108984	ENSMUSG00000020623
UniProt	P52564	P70236
RefSeq (mRNA)	NM_002758 NM_031988 NM_001330450	NM_011943
RefSeq (protein)	NP_001317379 NP_002749	NP_036073.1 NP_036073
Location (UCSC)	Chr 17: 69.41 – 69.54 Mb	Chr 11: 110.4 – 110.53 Mb
PubMed search

2Y8O, 3ENM, 3FME, 3VN9

5608

26399

ENSG00000108984

ENSMUSG00000020623

P52564

P70236

NM_002758
NM_031988
NM_001330450

NM_011943

NP_001317379
NP_002749

NP_036073.1
NP_036073

Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17.

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Wikipedia