MAML1

MAML1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F8X, 3NBN, 3V79
Identifiers
Aliases	MAML1, Mam-1, Mam1, mastermind like transcriptional coactivator 1
External IDs	MGI: 1890504 HomoloGene: 8845 GeneCards: MAML1
Gene ontology Molecular function • peptide antigen binding • transcription coactivator activity • protein binding • protein kinase binding Cellular component • nuclear speck • intracellular membrane-bounded organelle • nucleoplasm • nucleus • MAML1-RBP-Jkappa- ICN1 complex Biological process • Notch signaling pathway • positive regulation of myotube differentiation • atrioventricular node development • regulation of transcription, DNA-templated • positive regulation of muscle cell differentiation • atrioventricular node cell development • GO:0006350 transcription, DNA-templated • protein phosphorylation • positive regulation of transcription of Notch receptor target • myoblast differentiation • transcription initiation from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9794	103806
Ensembl	ENSG00000161021	ENSMUSG00000050567
UniProt	Q92585	Q6T264
RefSeq (mRNA)	NM_014757	NM_175334
RefSeq (protein)	NP_055572	NP_780543
Location (UCSC)	Chr 5: 179.73 – 179.8 Mb	Chr 11: 50.26 – 50.29 Mb
PubMed search

2F8X, 3NBN, 3V79

9794

103806

ENSG00000161021

ENSMUSG00000050567

Q92585

Q6T264

NM_014757

NM_175334

NP_055572

NP_780543

Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.

This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.

Details on the activity of the N-terminal domain of Mastermind-like protein 1 may be found under MamL-1.

MAML1 has been shown to interact with EP300 and NOTCH1.

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Wikipedia