NOTCH1

NOTCH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PB5, 1TOZ, 1YYH, 2F8X, 2F8Y, 2HE0, 2VJ3, 3ETO, 3I08, 3L95, 3NBN, 3V79, 4CUD, 4CUE, 4CUF, 4D0E, 4D0F, 5FM9, 5FMA
Identifiers
Aliases	NOTCH1, Notch1, 9930111A19Rik, Mis6, N1, Tan1, lin-12, AOS5, AOVD1, hN1, notch 1
External IDs	MGI: 97363 HomoloGene: 32049 GeneCards: NOTCH1
Gene ontology Molecular function • calcium ion binding • transcription factor activity, sequence-specific DNA binding • Notch binding • enzyme inhibitor activity • core promoter binding • metal ion binding • enzyme binding • chromatin binding • transcriptional activator activity, RNA polymerase II transcription factor binding • protein binding • receptor activity • sequence-specific DNA binding • protein heterodimerization activity • chromatin DNA binding Cellular component • cytoplasm • cytosol • membrane • adherens junction • extracellular region • nucleus • cell surface • apical plasma membrane • endoplasmic reticulum • integral component of membrane • Golgi apparatus • receptor complex • plasma membrane • nucleoplasm • MAML1-RBP-Jkappa- ICN1 complex • cell periphery • endoplasmic reticulum membrane • Golgi membrane • acrosomal vesicle • cytoplasmic vesicle Biological process • cardiac vascular smooth muscle cell development • endoderm development • pulmonary valve morphogenesis • positive regulation of endothelial cell differentiation • regulation of somitogenesis • cell differentiation in spinal cord • negative regulation of neuron differentiation • regulation of extracellular matrix assembly • distal tubule development • negative regulation of glial cell proliferation • epithelial to mesenchymal transition involved in endocardial cushion formation • regulation of transcription from RNA polymerase II promoter • aortic valve morphogenesis • oligodendrocyte differentiation • endocardium morphogenesis • negative regulation of osteoblast differentiation • negative regulation of stem cell differentiation • negative regulation of ossification • interleukin-4 secretion • heart looping • negative regulation of photoreceptor cell differentiation • arterial endothelial cell differentiation • regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation • atrioventricular valve morphogenesis • Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation • humoral immune response • foregut morphogenesis • negative regulation of oligodendrocyte differentiation • positive regulation of cardiac muscle cell proliferation • regulation of developmental process • mesenchymal cell development • animal organ regeneration • angiogenesis • spermatogenesis • negative regulation of pro-B cell differentiation • regulation of cardioblast proliferation • hair follicle morphogenesis • vasculogenesis involved in coronary vascular morphogenesis • negative regulation of canonical Wnt signaling pathway • regulation of neurogenesis • positive regulation of Notch signaling pathway • negative regulation of cell proliferation • collecting duct development • positive regulation of neuroblast proliferation • cilium morphogenesis • heart trabecula morphogenesis • atrioventricular node development • negative regulation of myoblast differentiation • cell fate commitment • regulation of transcription, DNA-templated • cellular response to follicle-stimulating hormone stimulus • lung development • negative regulation of auditory receptor cell differentiation • cardiac septum morphogenesis • ventricular septum morphogenesis • negative regulation of cell differentiation • coronary artery morphogenesis • response to muramyl dipeptide • cardiac left ventricle morphogenesis • in utero embryonic development • negative regulation of cell death • endocardial cell differentiation • transcription, DNA-templated • positive regulation of transcription, DNA-templated • heart development • prostate gland epithelium morphogenesis • embryonic limb morphogenesis • growth involved in heart morphogenesis • neural tube development • pericardium morphogenesis • epidermis development • cardiac atrium morphogenesis • transcription initiation from RNA polymerase II promoter • Notch signaling pathway • cardiac right atrium morphogenesis • negative regulation of cell-substrate adhesion • cell migration involved in endocardial cushion formation • cell differentiation • venous endothelial cell differentiation • regulation of auditory receptor cell differentiation • negative regulation of catalytic activity • inflammatory response to antigenic stimulus • positive regulation of astrocyte differentiation • positive regulation of epithelial cell proliferation • cardiac right ventricle formation • endocardial cushion development • cell fate specification • positive regulation of keratinocyte differentiation • positive regulation of glial cell differentiation • negative regulation of neurogenesis • glomerular mesangial cell development • sprouting angiogenesis • glial cell differentiation • negative regulation of transcription from RNA polymerase II promoter • cardiac muscle cell proliferation • secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development • positive regulation of epithelial to mesenchymal transition • ventricular trabecula myocardium morphogenesis • neuronal stem cell population maintenance • negative regulation of cell migration involved in sprouting angiogenesis • response to lipopolysaccharide • compartment pattern specification • positive regulation of transcription of Notch receptor target • immune response • neuron differentiation • epithelial to mesenchymal transition • positive regulation of BMP signaling pathway • skeletal muscle cell differentiation • regulation of gene expression • positive regulation of viral genome replication • regulation of epithelial cell proliferation involved in prostate gland development • negative regulation of transcription, DNA-templated • cardiac ventricle morphogenesis • branching morphogenesis of an epithelial tube • positive regulation of JAK-STAT cascade • negative regulation of anoikis • Notch signaling involved in heart development • coronary vein morphogenesis • apoptotic process involved in embryonic digit morphogenesis • regulation of cell migration • axonogenesis • tissue regeneration • positive regulation of cell migration • somatic stem cell division • cardiac muscle tissue morphogenesis • negative regulation of endothelial cell chemotaxis • keratinocyte differentiation • negative regulation of BMP signaling pathway • endocardial cushion morphogenesis • endocardium development • multicellular organism development • auditory receptor cell fate commitment • response to corticosteroid • tube formation • determination of left/right symmetry • astrocyte differentiation • negative regulation of calcium ion-dependent exocytosis • brain development • regulation of cell proliferation • positive regulation of cell proliferation • negative regulation of myotube differentiation • positive regulation of apoptotic process • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • mitral valve formation • liver development • cardiac chamber formation • forebrain development • cellular response to vascular endothelial growth factor stimulus • neuron fate commitment • regulation of epithelial cell proliferation • regulation of Notch signaling pathway • left/right axis specification • positive regulation of transcription from RNA polymerase II promoter • cardiac epithelial to mesenchymal transition • embryonic hindlimb morphogenesis • positive regulation of aorta morphogenesis • venous blood vessel morphogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4851	18128
Ensembl	ENSG00000148400	ENSMUSG00000026923
UniProt	P46531	Q01705
RefSeq (mRNA)	NM_017617	NM_008714
RefSeq (protein)	NP_060087	NP_032740.3 NP_032740
Location (UCSC)	Chr 9: 136.49 – 136.55 Mb	Chr 2: 26.46 – 26.52 Mb
PubMed search

1PB5, 1TOZ, 1YYH, 2F8X, 2F8Y, 2HE0, 2VJ3, 3ETO, 3I08, 3L95, 3NBN, 3V79, 4CUD, 4CUE, 4CUF, 4D0E, 4D0F, 5FM9, 5FMA

4851

18128

ENSG00000148400

ENSMUSG00000026923

P46531

...
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