Luteinizing hormone-releasing hormone

GNRH1
Identifiers
Aliases	GNRH1, GNRH, GRH, HH12, LHRH, LNRH, gonadotropin releasing hormone 1, Gonadotropin-Releasing Hormone
External IDs	OMIM: 152760 MGI: 95789 HomoloGene: 641 GeneCards: GNRH1
Gene location (Human) Chr. Chromosome 8 (human) Band 8p21.2 Start 25,419,260 bp End 25,424,654 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 D1 Start 67,745,181 bp End 67,749,439 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • hormone activity • gonadotropin hormone-releasing hormone activity Cellular component • axon terminus • perikaryon • Golgi-associated vesicle • extracellular region • neurosecretory vesicle • dendrite • mitochondrion • neuron projection • cytoplasmic side of rough endoplasmic reticulum membrane • extracellular space Biological process • negative regulation of immature T cell proliferation • response to prolactin • negative regulation of neuron migration • response to potassium ion • response to organic cyclic compound • response to testosterone • estrous cycle • female pregnancy • cell-cell signaling • response to steroid hormone • aging • response to peptide hormone • negative regulation of apoptotic process • male sex determination • multicellular organism development • response to prostaglandin E • response to lipopolysaccharide • response to corticosteroid • regulation of gene expression • ovulation cycle • response to ethanol • regulation of ovarian follicle development • signal transduction • negative regulation of cell proliferation • regulation of receptor activity • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2796	14714
Ensembl	ENSG00000147437	ENSMUSG00000015812
UniProt	P01148	P13562
RefSeq (mRNA)	NM_001083111 NM_000825	NM_008145
RefSeq (protein)	NP_000816 NP_001076580	NP_032171
Location (UCSC)	Chr 8: 25.42 – 25.42 Mb	Chr 8: 67.75 – 67.75 Mb
PubMed search

2796

14714

ENSG00000147437

ENSMUSG00000015812

P01148

P13562

NM_001083111
NM_000825

NM_008145

NP_000816
NP_001076580

NP_032171

Gonadotropin-releasing hormone (GnRH) also known as gonadoliberin, and by various other names in its endogenous form and as gonadorelin (INN) in its pharmaceutical form, is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is a tropic peptide hormone synthesized and released from GnRH neurons within the hypothalamus. The peptide belongs to gonadotropin-releasing hormone family. It constitutes the initial step in the hypothalamic–pituitary–gonadal axis.

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