Luis de Bolaños (1549? – 11 October 1629) was a Spanish Franciscan friar and missionary evangelist, initiator of the system of reductions (indigenous towns) in Paraguay and northeastern Argentina.
Bolaños was born in Marchena, Seville, and entered the Franciscan order while he was very young, studying until he became a deacon. Friar Alonso de San Buenaventura passed by his convent looking for missionaries to work in South America, and Bolaños joined his group. Twenty-two Franciscans departed from Spain in the 1572 expedition of the Adelantado Juan Ortiz de Zárate. They arrived in Asunción (the present-day capital of Paraguay) in 1575.
Bolaños was ordained a priest in 1585. For fifty more years he worked on the evangelization of the Guaraní aboriginals. He created the system of reductions, settlements populated by natives and overseen by the friars of the Order, of which the Jesuit Reductions would then become their most renowned examples. These towns "reduced" the originally nomadic natives to fixed, stable locations, allowing the missionaries to better control and catechize them, while teaching them to read and write, to cultivate the land, to domesticate animals, and to create manual artistic works. The Franciscan friar founded reductions all over the basin of the Paraná River, in Paraguay, large parts of Brazil, and the Argentine provinces of Misiones and northern Corrientes.