Prince Luigi Amedeo, Duke of the Abruzzi (January 29, 1873 – March 18, 1933) was an Italian mountaineer and explorer, member of the royal House of Savoy and cousin of the Italian King Victor Emmanuel III. He is known for his Arctic explorations and for his mountaineering expeditions, particularly to Mount Saint Elias (Alaska–Yukon) and K2 (Pakistan–China). He also served as an Italian admiral during World War I.

He was born in Madrid, Spain as the third oldest son of Prince Amadeo of Savoy, Duke of Aosta and his first wife Donna Maria Vittoria dal Pozzo della Cisterna. Prince Luigi Amedeo was a grandson of King Vittorio Emanuele II of Italy. He was born during his father's brief reign as King Amadeo of Spain. His siblings are Prince Emanuele Filiberto, Prince Vittorio Emanuele, and Prince Umberto. Shortly after his birth his father, who had reigned in Spain since 1870, abdicated and returned to Italy in 1873. Prince Luigi Amedeo was a member of the House of Savoy, well known in Europe since the 12th century. His uncle became King Umberto I of Italy in 1878, and his cousin became King Vittorio Emanuele III in 1900.