Lamin B receptor

LBR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DIG
Identifiers
Aliases	LBR, DHCR14B, LMN2R, PHA, TDRD18, lamin B receptor
External IDs	OMIM: 600024 MGI: 2138281 HomoloGene: 2455 GeneCards: LBR
Gene ontology Molecular function • oxidoreductase activity, acting on the CH-CH group of donors • DNA binding • oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor • protein binding • chromo shadow domain binding • lamin binding • delta14-sterol reductase activity • RNA binding Cellular component • integral component of membrane • integral component of endoplasmic reticulum membrane • nuclear inner membrane • integral component of nuclear inner membrane • nuclear membrane • nuclear envelope • membrane • nucleus Biological process • cholesterol biosynthetic process • sterol biosynthetic process • oxidation-reduction process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3930	98386
Ensembl	ENSG00000143815	ENSMUSG00000004880
UniProt	Q14739	Q3U9G9
RefSeq (mRNA)	NM_002296 NM_194442	NM_133815
RefSeq (protein)	NP_002287 NP_919424	NP_598576
Location (UCSC)	Chr 1: 225.4 – 225.43 Mb	Chr 1: 181.82 – 181.84 Mb
PubMed search

2DIG

3930

98386

ENSG00000143815

ENSMUSG00000004880

Q14739

Q3U9G9

NM_002296
NM_194442

NM_133815

NP_002287
NP_919424

NP_598576

Lamin-B receptor is a protein, and in humans, it is encoded by the LBR gene.

The protein encoded by this gene belongs to the ERG4/ERG24 family. It localizes to the inner membrane of the nuclear envelope and anchors the lamina and the heterochromatin to the membrane. It may mediate the interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

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