LKB1

STK11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WTK, 4ZDR
Identifiers
Aliases	STK11, LKB1, PJS, hLKB1, serine/threonine kinase 11
External IDs	MGI: 1341870 HomoloGene: 393 GeneCards: STK11
Gene ontology Molecular function • transferase activity • nucleotide binding • LRR domain binding • protein kinase activity • p53 binding • protein kinase activator activity • metal ion binding • kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • magnesium ion binding Cellular component • cytoplasm • membrane • mitochondrion • extracellular exosome • TCR signalosome • nucleus • nucleoplasm • cytosol Biological process • response to ionizing radiation • positive regulation of transforming growth factor beta receptor signaling pathway • dendrite extension • TCR signalosome assembly • axonogenesis • glucose homeostasis • positive regulation of autophagy • phosphorylation • negative regulation of lipid biosynthetic process • positive regulation of axonogenesis • cellular response to DNA damage stimulus • regulation of dendrite morphogenesis • autophagy • protein phosphorylation • Golgi localization • regulation of Wnt signaling pathway • vasculature development • anoikis • cellular response to UV-B • negative regulation of cell growth • regulation of cell growth • cell cycle arrest • tissue homeostasis • establishment of cell polarity • positive thymic T cell selection • positive regulation of peptidyl-tyrosine phosphorylation • regulation of protein kinase B signaling • canonical Wnt signaling pathway • intrinsic apoptotic signaling pathway by p53 class mediator • protein autophosphorylation • cell cycle • negative regulation of epithelial cell proliferation involved in prostate gland development • T cell receptor signaling pathway • spermatogenesis • activation of protein kinase activity • negative regulation of TORC1 signaling • negative regulation of cell proliferation • positive regulation of protein localization to nucleus • apoptotic process • regulation of signal transduction by p53 class mediator • nervous system development • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • cell differentiation • positive regulation of protein serine/threonine kinase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6794	20869
Ensembl	ENSG00000118046	ENSMUSG00000003068
UniProt	Q15831	Q9WTK7
RefSeq (mRNA)	NM_000455	NM_001301853 NM_001301854 NM_011492
RefSeq (protein)	NP_000446	NP_001288782.1 NP_001288783.1 NP_035622.1 NP_001288782 NP_001288783 NP_035622
Location (UCSC)	Chr 19: 1.18 – 1.23 Mb	Chr 10: 80.12 – 80.13 Mb
PubMed search

2WTK, 4ZDR

6794

20869

ENSG00000118046

ENSMUSG00000003068

Q15831

Q9WTK7

NM_000455

NM_001301853
NM_001301854
NM_011492

NP_000446

NP_035622

Serine/threonine kinase 11 (STK11) also known as liver kinase B1 (LKB1) or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the STK11 gene.

Testosterone and DHT treatment of murine 3T3-L1 or human SGBS adipocytes for 24 h significantly decreased the mRNA expression of LKB1 via the androgen receptor and consequently reduced the activation of AMPK by phosphorylation. In contrast, 17β-estradiol treatment increased LKB1 mRNA, an effect mediated by oestrogen receptor alpha.

...
Wikipedia