Kir6.2

KCNJ11
Identifiers
Aliases	KCNJ11, BIR, HHF2, IKATP, KIR6.2, MODY13, PHHI, TNDM3, potassium voltage-gated channel subfamily J member 11
External IDs	OMIM: 600937 MGI: 107501 HomoloGene: 441 GeneCards: KCNJ11
Genetically Related Diseases
type 2 diabetes mellitus
Targeted by Drug
minoxidil, nicorandil, glyburide, tolbutamide
Gene ontology Molecular function • heat shock protein binding • ion channel binding • potassium ion binding • voltage-gated ion channel activity • protein C-terminus binding • ankyrin binding • voltage-gated potassium channel activity • ATP-activated inward rectifier potassium channel activity • inward rectifier potassium channel activity • ATP binding Cellular component • integral component of membrane • cytosol • endosome • nuclear envelope • membrane • intracellular membrane-bounded organelle • intercalated disc • cell body fiber • T-tubule • myelin sheath • voltage-gated potassium channel complex • plasma membrane • integral component of plasma membrane • neuronal cell body • endoplasmic reticulum • mitochondrion • axolemma • ATP-sensitive potassium channel complex • sarcolemma Biological process • positive regulation of cation channel activity • response to ATP • response to estradiol • negative regulation of insulin secretion • regulation of cardiac conduction • regulation of insulin secretion • response to testosterone • regulation of membrane potential • cellular response to tumor necrosis factor • regulation of ion transmembrane transport • neurological system process • cellular response to nicotine • ion transport • potassium ion transport • response to ischemia • transmembrane transport • potassium ion transmembrane transport • glucose metabolic process • transport • response to drug • cellular response to glucose stimulus • potassium ion import • positive regulation of protein targeting to membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3767	16514
Ensembl	ENSG00000187486	ENSMUSG00000096146
UniProt	Q14654	Q61743
RefSeq (mRNA)	NM_000525 NM_001166290	NM_001204411 NM_010602
RefSeq (protein)	NP_000516 NP_001159762	NP_034732.1 NP_001191340 NP_034732
Location (UCSC)	Chr 11: 17.39 – 17.39 Mb	Chr 7: 46.09 – 46.1 Mb
PubMed search

3767

16514

ENSG00000187486

ENSMUSG00000096146

Q14654

Q61743

NM_000525
NM_001166290

NM_001204411
NM_010602

NP_000516
NP_001159762

NP_034732.1
NP_001191340
NP_034732

K_ir6.2 is a major subunit of the ATP-sensitive K⁺ channel, an inward-rectifier potassium ion channel. The gene encoding the channel is called KCNJ11 and mutations in this gene are associated with congenital hyperinsulinism.

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Wikipedia