Kameda Domain (亀田藩 Kameda-han?) was a feudal domain in Edo period Japan, located in Dewa Province (modern-day Akita Prefecture), Japan. It was centered on Kameda Castle in what is now the city of Yurihonjō, Akita.
Much of Dewa Province was controlled by the powerful Mogami clan during the Sengoku period. However, the Mogami were dispossessed by the Tokugawa shogunate in 1622, with the majority of their holdings going to the Satake clan, who were transferred from Hitachi Province, to their new (and much smaller) holdings at Kubota Domain.
The Iwaki clan originally ruled a 120,000 koku domain in the Hamadōri region of southeast Mutsu Province since the Kamakura period, and had established close ties to both the Date clan of Sendai and the Satake clan of Hitachi during the late Sengoku period. Although the Iwaki clan sided with Tokugawa Ieyasu at the Battle of Sekigahara, due to their close familial ties with Satake Yoshinobu, they refused to participate in attack Ieyasu ordered on Uesugi Kagekatsu at Aizuwakamatsu and were consequently dispossessed of their holdings.