KLF2

KLF2
Identifiers
Aliases	KLF2, LKLF, Kruppel-like factor 2, Kruppel like factor 2
External IDs	MGI: 1342772 HomoloGene: 133978 GeneCards: KLF2
Gene ontology Molecular function • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • metal ion binding • protein binding • nucleic acid binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • DNA binding Cellular component • nucleus • nuclear chromatin Biological process • cellular response to peptide • regulation of transcription, DNA-templated • regulation of gene expression, epigenetic • multicellular organism growth • cellular response to laminar fluid shear stress • positive regulation of transcription from RNA polymerase II promoter in response to stress • positive regulation of nitric oxide biosynthetic process • negative regulation of interleukin-6 production • cellular response to tumor necrosis factor • cellular response to organic cyclic compound • response to laminar fluid shear stress • in utero embryonic development • transcription, DNA-templated • positive regulation of protein metabolic process • positive regulation of transcription, DNA-templated • erythrocyte homeostasis • Type I pneumocyte differentiation • cellular response to interleukin-1 • cell morphogenesis • cellular response to cycloheximide • cellular response to hydrogen peroxide • erythrocyte maturation • positive regulation of transcription from RNA polymerase II promoter • cellular response to fluid shear stress Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10365	16598
Ensembl	ENSG00000127528	ENSMUSG00000055148
UniProt	Q9Y5W3	Q60843
RefSeq (mRNA)	NM_016270	NM_008452
RefSeq (protein)	NP_057354	NP_032478
Location (UCSC)	Chr 19: 16.32 – 16.33 Mb	Chr 8: 72.32 – 72.32 Mb
PubMed search

10365

16598

ENSG00000127528

ENSMUSG00000055148

Q9Y5W3

Q60843

NM_016270

NM_008452

NP_057354

NP_032478

Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19. It is a member of the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.

Erythroid Krüppel-like Factor (EKLF or KLF1) was the first Krüppel-like Factor discovered. It was found to be vitally important for embryonic erythropoiesis in promoting the switch from fetal hemoglobin (Hemoglobin F) to adult hemoglobin (Hemoglobin A) gene expression by binding to highly conserved CACCC domains.EKLF ablation in mouse embryos produces a lethal anemic phenotype, causing death by embryonic day 14, and natural mutations lead to β+ thalassemia in humans. However, expression of embryonic hemoglobin and fetal hemoglobin genes is normal in EKLF-deficient mice, and since all genes on the human β-globin locus exhibit the CACCC elements, researchers began searching for other Krüppel-like factors.

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Wikipedia