KCNK3

KCNK3
Identifiers
Aliases	KCNK3, K2p3.1, OAT1, PPH4, TASK, TASK-1, TBAK1, potassium two pore domain channel subfamily K member 3
External IDs	MGI: 1100509 HomoloGene: 1692 GeneCards: KCNK3
Targeted by Drug
anandamide
Gene ontology Molecular function • S100 protein binding • potassium channel activity • protein homodimerization activity • open rectifier potassium channel activity • potassium ion leak channel activity • ion channel activity • protein C-terminus binding • protein heterodimerization activity • growth factor activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • extracellular space Biological process • cochlea development • ion transport • cellular response to zinc ion • potassium ion transport • ion transmembrane transport • brain development • cardiac conduction • potassium ion transmembrane transport • transport • cellular response to hypoxia • response to drug • negative regulation of cytosolic calcium ion concentration • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3777	16527
Ensembl	ENSG00000171303	ENSMUSG00000049265
UniProt	O14649	O35111
RefSeq (mRNA)	NM_002246	NM_010608
RefSeq (protein)	NP_002237	NP_034738.1 NP_034738
Location (UCSC)	Chr 2: 26.69 – 26.73 Mb	Chr 5: 30.59 – 30.63 Mb
PubMed search

3777

16527

ENSG00000171303

ENSMUSG00000049265

O14649

O35111

NM_002246

NM_010608

NP_002237

NP_034738.1
NP_034738

Potassium channel subfamily K member 3 is a protein that in humans is encoded by the KCNK3 gene.

This gene encodes K_2P3.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K_2P3.1 is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.

Click on genes, proteins and metabolites below to link to respective articles.

KCNK3 has been shown to interact with YWHAB and S100A10.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Wikipedia